19727074 |
A dimerization-dependent mechanism drives RAF catalytic activation
Rajakulendran, T,
Sahmi, M,
Lefrancois, M,
Sicheri, F,
Therrien, M
|
Nature |
2009 |
25907612 |
Regulation of RAF protein kinases in ERK signalling
Lavoie, H,
Therrien, M
|
Nat. Rev. Mol. Cell Biol. |
2015 |
24957944 |
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
Holderfield, M,
Deuker, MM,
McCormick, F,
McMahon, M
|
Nat. Rev. Cancer |
2014 |
23352452 |
Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling
Freeman, AK,
Ritt, DA,
Morrison, DK
|
Mol. Cell |
2013 |
20141835 |
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
Heidorn, SJ,
Milagre, C,
Whittaker, S,
Nourry, A,
Niculescu-Duvas, I,
Dhomen, N,
Hussain, J,
Reis-Filho, JS,
Springer, CJ,
Pritchard, C,
Marais, R
|
Cell |
2010 |
16364920 |
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
Garnett, MJ,
Rana, S,
Paterson, H,
Barford, D,
Marais, R
|
Mol. Cell |
2005 |
25435214 |
Targeting RAS-ERK signalling in cancer: promises and challenges
Samatar, AA,
Poulikakos, PI
|
Nat Rev Drug Discov |
2014 |
20674547 |
RAF protein-serine/threonine kinases: structure and regulation
Roskoski, R Jr
|
Biochem. Biophys. Res. Commun. |
2010 |
29084939 |
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
Jin, T,
Lavoie, H,
Sahmi, M,
David, M,
Hilt, C,
Hammell, A,
Therrien, M
|
Nat Commun |
2017 |
20179705 |
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikakos, PI,
Zhang, C,
Bollag, G,
Shokat, KM,
Rosen, N
|
Nature |
2010 |
28984291 |
New perspectives for targeting RAF kinase in human cancer
Karoulia, Z,
Gavathiotis, E,
Poulikakos, PI
|
Nat. Rev. Cancer |
2017 |
22510884 |
Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
Röring, M,
Herr, R,
Fiala, GJ,
Heilmann, K,
Braun, S,
Eisenhardt, AE,
Halbach, S,
Capper, D,
von Deimling, A,
Schamel, WW,
Saunders, DN,
Brummer, T
|
EMBO J. |
2012 |
27523909 |
An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling
Karoulia, Z,
Wu, Y,
Ahmed, TA,
Xin, Q,
Bollard, J,
Krepler, C,
Wu, X,
Zhang, C,
Bollag, G,
Herlyn, M,
Fagin, JA,
Lujambio, A,
Gavathiotis, E,
Poulikakos, PI
|
Cancer Cell |
2016 |
23680146 |
RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation
Holderfield, M,
Merritt, H,
Chan, J,
Wallroth, M,
Tandeske, L,
Zhai, H,
Tellew, J,
Hardy, S,
Hekmat-Nejad, M,
Stuart, DD,
McCormick, F,
Nagel, TE
|
Cancer Cell |
2013 |
20130576 |
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Hatzivassiliou, G,
Song, K,
Yen, I,
Brandhuber, BJ,
Anderson, DJ,
Alvarado, R,
Ludlam, MJ,
Stokoe, D,
Gloor, SL,
Vigers, G,
Morales, T,
Aliagas, I,
Liu, B,
Sideris, S,
Hoeflich, KP,
Jaiswal, BS,
Seshagiri, S,
Koeppen, H,
Belvin, M,
Friedman, LS,
Malek, S
|
Nature |
2010 |
15035987 |
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
Wan, PT,
Garnett, MJ,
Roe, SM,
Lee, S,
Niculescu-Duvaz, D,
Good, VM,
Jones, CM,
Marshall, CJ,
Springer, CJ,
Barford, D,
Marais, R
|
Cell |
2004 |