Reactome | TP53 Regulates Transcription of Caspase Activators and Caspases

TP53 Regulates Transcription of Caspase Activators and Caspases

Stable Identifier

R-HSA-6803207

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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TP53 Regulates Transcription of Caspase Activators and Caspases

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TP53 (p53) transcriptionally regulates cytosolic caspase activators, such as APAF1, PIDD1, and NLRC4, and caspases themselves, such as CASP1, CASP6 and CASP10. These caspases and their activators are involved either in the intrinsic apoptosis pathway or in the extrinsic apoptosis pathway triggerred by death receptors or the inflammation-related cell death pyroptosis (Lin et al. 2000, Robles et al. 2001, Gupta et al. 2001, MacLachlan and El-Deiry 2002, Rikhof et al. 2003, Sadasivam et al. 2005, Brough and Rothwell 2007).

Literature References

PubMed ID	Title	Journal	Year
11559530	APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis Bemmels, NA, Robles, AI, Harris, CC, Foraker, AB	Cancer Res.	2001
14688482	Caspase 10 levels are increased following DNA damage in a p53-dependent manner Rikhof, B, Corn, PG, El-Deiry, WS	Cancer Biol. Ther.	2003
12089322	Apoptotic threshold is lowered by p53 transactivation of caspase-6 MacLachlan, TK, El-Deiry, WS	Proc. Natl. Acad. Sci. U.S.A.	2002
11278253	Direct transcriptional activation of human caspase-1 by tumor suppressor p53 Furukawa, Y, Swarup, G, Gupta, S, Radha, V	J. Biol. Chem.	2001
15580302	Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis Gupta, S, Radha, V, Kundu, TK, Batta, K, Swarup, G, Sadasivam, S	Oncogene	2005
10973264	Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis Ma, W, Benchimol, S, Lin, Y	Nat. Genet.	2000
17284521	Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death Rothwell, NJ, Brough, D	J Cell Sci	2007