TP53 Regulates Transcription of Caspase Activators and Caspases

Stable Identifier
R-HSA-6803207
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Pathway
Species
Homo sapiens
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TP53 Regulates Transcription of Caspase Activators and Caspases
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TP53 (p53) transcriptionally regulates cytosolic caspase activators, such as APAF1, PIDD1, and NLRC4, and caspases themselves, such as CASP1, CASP6 and CASP10. These caspases and their activators are involved either in the intrinsic apoptosis pathway or in the extrinsic apoptosis pathway triggerred by death receptors or the inflammation-related cell death pyroptosis (Lin et al. 2000, Robles et al. 2001, Gupta et al. 2001, MacLachlan and El-Deiry 2002, Rikhof et al. 2003, Sadasivam et al. 2005, Brough and Rothwell 2007).

Literature References
PubMed ID Title Journal Year
14688482 Caspase 10 levels are increased following DNA damage in a p53-dependent manner

Rikhof, B, Corn, PG, El-Deiry, WS

Cancer Biol. Ther. 2003
11559530 APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis

Robles, AI, Bemmels, NA, Foraker, AB, Harris, CC

Cancer Res. 2001
12089322 Apoptotic threshold is lowered by p53 transactivation of caspase-6

MacLachlan, TK, El-Deiry, WS

Proc. Natl. Acad. Sci. U.S.A. 2002
11278253 Direct transcriptional activation of human caspase-1 by tumor suppressor p53

Gupta, S, Radha, V, Furukawa, Y, Swarup, G

J. Biol. Chem. 2001
15580302 Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

Sadasivam, S, Gupta, S, Radha, V, Batta, K, Kundu, TK, Swarup, G

Oncogene 2005
10973264 Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

Lin, Y, Ma, W, Benchimol, S

Nat. Genet. 2000
17284521 Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

Brough, D, Rothwell, NJ

J Cell Sci 2007
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Orthologous Events
TP53 Regulates Transcription of Caspase Activators and Caspases (Bos taurus)
TP53 Regulates Transcription of Caspase Activators and Caspases (Canis familiaris)
TP53 Regulates Transcription of Caspase Activators and Caspases (Danio rerio)
TP53 Regulates Transcription of Caspase Activators and Caspases (Gallus gallus)
TP53 Regulates Transcription of Caspase Activators and Caspases (Mus musculus)
TP53 Regulates Transcription of Caspase Activators and Caspases (Rattus norvegicus)
TP53 Regulates Transcription of Caspase Activators and Caspases (Sus scrofa)
TP53 Regulates Transcription of Caspase Activators and Caspases (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-05)