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SPINT1 [extracellular region]
Stable Identifier
R-HSA-6800232
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Kunitz-type protease inhibitor 1, SPIT1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q01167 FOXK2
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET Receptor Activation (Homo sapiens)
HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)
SPINT1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43278 SPINT1
Gene Names
SPINT1, HAI1, UNQ223/PRO256
Chain
signal peptide:1-35, chain:36-529
Reference Genes
BioGPS Gene:6692 SPINT1
COSMIC - genes:SPINT1 SPINT1
CTD Gene:6692 SPINT1
dbSNP Gene:6692 SPINT1
ENSEMBL:ENSG00000166145 SPINT1
HGNC:11246 SPINT1
KEGG:hsa:6692 SPINT1
Monarch:6692 SPINT1
NCBI Gene:6692 SPINT1
OMIM:605123 SPINT1
UCSC:O43278 SPINT1
Reference Transcript
RefSeq:NM_181642.3 SPINT1
RefSeq:NM_003710.4 SPINT1
RefSeq:NM_001032367.2 SPINT1
RefSeq:NM_001386873.1 SPINT1
RefSeq:XM_047432968.1 SPINT1
RefSeq:XM_054378666.1 SPINT1
Participates
as a member of
SPINT1,2 [extracellular region] (Homo sapiens)
This entity regulates
Negatively
HGFAC cleaves pro-HGF to form HGF dimer
(Homo sapiens)
Inferred To
SPINT1 [extracellular region]
(Bos taurus)
SPINT1 [extracellular region]
(Canis familiaris)
SPINT1 [extracellular region]
(Gallus gallus)
SPINT1 [extracellular region]
(Sus scrofa)
spint1a [extracellular region]
(Danio rerio)
Spint1 [extracellular region]
(Mus musculus)
Spint1 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001373802.1
,
NP_001027539.1
,
XP_047288924.1
,
XP_054234641.1
,
NP_857593.1
,
NP_003701.1
ENSEMBL
ENST00000344051
,
ENSP00000457076
,
ENSP00000342098
,
ENST00000562057
,
ENSG00000166145
OpenTargets
ENSG00000166145
GeneCards
SPINT1
HPA
ENSG00000166145-SPINT1
PRO
O43278
Pharos - Targets
O43278
GlyGen
O43278
PDB
5EZD
,
4ISO
,
5H7V
,
4ISL
,
2MSX
,
4ISN
,
1YC0
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04756 HGFAC
2
HGFAC(408-655) [cytosol]
(R-HSA-6800283)
HGFAC(373-407) [cytosol]
(R-HSA-1641473)
0.688
3
UniProt:P85037 FOXK1
1
FOXK1 [nucleoplasm]
(R-HSA-5689673)
0.527
2
UniProt:Q01167 FOXK2
1
FOXK2 [nucleoplasm]
(R-HSA-5689655)
0.527
2
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