Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HGFAC(373-407) [cytosol]
Stable Identifier
R-HSA-1641473
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HGFAC short chain, Hepatocyte growth factor activator, HGFA_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET Receptor Activation (Homo sapiens)
HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)
HGFAC dimer [extracellular region] (Homo sapiens)
HGFAC(373-407) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04756 HGFAC
Gene Names
HGFAC
Chain
signal peptide:1-35, propeptide:36-372, chain:373-407, chain:408-655
Reference Genes
BioGPS Gene:3083 HGFAC
COSMIC (genes):HGFAC HGFAC
CTD Gene:3083 HGFAC
dbSNP Gene:3083 HGFAC
ENSEMBL:ENSG00000109758 HGFAC
HGNC:4894 HGFAC
KEGG:hsa:3083 HGFAC
Monarch:3083 HGFAC
NCBI Gene:3083 HGFAC
OMIM:604552 HGFAC
UCSC:Q04756 HGFAC
Reference Transcript
RefSeq:NM_001528.3 HGFAC
RefSeq:NM_001297439.1 HGFAC
Other Identifiers
11731985_a_at
16964455
207027_PM_at
207027_at
2716125
2716126
2716127
2716128
2716129
2716130
2716131
2716132
2716134
2716135
2716136
2716137
2716138
2716139
2716141
2716142
2716143
2716144
2716145
2716146
2716147
3083
35063_at
8093792
A_14_P100714
A_23_P58108
A_33_P3267640
GE57236
GO:0003824
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005783
GO:0005791
GO:0005829
GO:0006508
GO:0007596
GO:0008236
GO:0016787
GO:0031638
GO:0043226
GO:0051604
GO:0140096
HMNXSV003035355
ILMN_1701468
PH_hs_0000015
TC04000047.hg
Z69923_at
g4504382_3p_at
Participates
as a component of
HGFAC dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
HGFAC(408-655) [cytosol]
Inferred To
Hgfac [cytosol]
(Mus musculus)
Hgfac [cytosol]
(Rattus norvegicus)
HGFAC [cytosol]
(Bos taurus)
HGFAC [cytosol]
(Canis familiaris)
HGFAC [cytosol]
(Sus scrofa)
HGFAC(373-407) [cytosol]
(Gallus gallus)
Cross References
RefSeq
NP_001519.1
,
NP_001284368.1
ZINC - World Drugs
HGFA_HUMAN
ENSEMBL
ENST00000382774
,
ENSP00000372224
OpenTargets
ENSG00000109758
HPA
ENSG00000109758-HGFAC
ZINC - Substances
HGFA_HUMAN
ZINC target
Q04756
PRO
Q04756
Pharos - Targets
Q04756
GlyGen
Q04756
ZINC - Predictions - Purchasable
HGFA_HUMAN
PDB
2R0L
,
1YBW
,
3K2U
,
2WUC
,
1YC0
,
2WUB
,
2R0K
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43278 SPINT1
1
SPINT1 [extracellular region]
(R-HSA-6800232)
0.59
2
UniProt:Q9BRI3 SLC30A2
2
SLC30A2 [endosome membrane]
(R-HSA-435363)
SLC30A2 [synaptic vesicle membrane]
(R-HSA-4084714)
0.556
3
UniProt:P05154 SERPINA5
1
SERPINA5 [extracellular region]
(R-HSA-5591085)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text