Reactome | LPPR1 [plasma membrane]

LPPR1 [plasma membrane]

Stable Identifier

R-HSA-6797625

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Lipid phosphate phosphatase-related protein type 1, LPPR1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Lysosphingolipid and LPA receptors (Homo sapiens)
        
        LRPP4(LRPP1-3,5) hydrolyse LPA (Homo sapiens)
        
        LPPR4(LPPR1-3,5) [plasma membrane] (Homo sapiens)
        
        LPPR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TBJ4 PLPPR1

Gene Names

PLPPR1, LPPR1, PRG3

Chain

chain:1-325

Reference Genes

BioGPS Gene:54886 PLPPR1

COSMIC (genes):PLPPR1 PLPPR1

CTD Gene:54886 PLPPR1

dbSNP Gene:54886 PLPPR1

ENSEMBL:ENSG00000148123 PLPPR1

ENSEMBL:ENSG00000148123.15 PLPPR1

ENSEMBL:ENSG00000276539.4 PLPPR1

HGNC:25993 PLPPR1

KEGG Gene (Homo sapiens):54886 PLPPR1

Monarch:54886 PLPPR1

NCBI Gene:54886 PLPPR1

OMIM:619590 PLPPR1

UCSC:Q8TBJ4 PLPPR1

Reference Transcript

Other Identifiers

0006940020

11726598_a_at

11726599_a_at

17087615

219732_PM_at

219732_at

3182331

3182332

3182333

3182347

3182348

3182349

3182358

3182360

3182361

3182369

3182370

3182371

3182372

3182373

49989_at

54886

8156923

A_14_P104855

A_14_P111675

A_23_P259707

GE55437

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005886

GO:0005887

GO:0006629

GO:0006644

GO:0007165

GO:0007399

GO:0008150

GO:0008195

GO:0016020

GO:0016021

GO:0016791

GO:0023052

GO:0042577

GO:0042995

GO:0043005

GO:0043226

GO:0046839

GO:0048856

HMNXSV003049058

ILMN_1663124

ILMN_1753026

ILMN_1780576

ILMN_2234930

PH_hs_0024356

TC09000515.hg

g8923280_3p_at

Participates

as a candidate of

LPPR4(LPPR1-3,5) [plasma membrane] (Homo sapiens)

Inferred To

LPPR1 [plasma membrane] (Canis familiaris)

LPPR1 [plasma membrane] (Dictyostelium discoideum)

wun [plasma membrane] (Drosophila melanogaster)

plpp-1.2 [plasma membrane] (Caenorhabditis elegans)

DPP1 [plasma membrane] (Saccharomyces cerevisiae)

plppr1 [plasma membrane] (Danio rerio)

PLPPR1 [plasma membrane] (Bos taurus)

PLPPR1 [plasma membrane] (Gallus gallus)

PLPPR1 [plasma membrane] (Sus scrofa)

Plppr1 [plasma membrane] (Mus musculus)

Plppr1 [plasma membrane] (Rattus norvegicus)

plpr-1 [plasma membrane] (Caenorhabditis elegans)

LPP1 [plasma membrane] (Saccharomyces cerevisiae)

WUN-like [plasma membrane] (Drosophila melanogaster)

dpp1 [plasma membrane] (Schizosaccharomyces pombe)

plpp-1.1 [plasma membrane] (Caenorhabditis elegans)

plpp-1.3 [plasma membrane] (Caenorhabditis elegans)

Homologues of LPPR1 [plasma membrane] (Caenorhabditis elegans)

Homologues of LPPR1 [plasma membrane] (Dictyostelium discoideum)

Homologues of LPPR1 [plasma membrane] (Drosophila melanogaster)

Homologues of LPPR1 [plasma membrane] (Saccharomyces cerevisiae)

LPP-like [plasma membrane] (Drosophila melanogaster)

wun2 [plasma membrane] (Drosophila melanogaster)

laza [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_997182.1, NP_060223.2

OpenTargets

ENSG00000148123

HPA

ENSG00000148123-PLPPR1

GeneCards

Q8TBJ4

Ensembl

ENSG00000148123, ENST00000614834, ENST00000374874, ENSP00000378496, ENST00000395056, ENST00000611695, ENSG00000276539, ENSP00000478338, ENSP00000364008, ENSP00000477959

PRO

Q8TBJ4

Pharos - Targets

Q8TBJ4

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3

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