Reactome | LPPR1 [plasma membrane]

LPPR1 [plasma membrane]

Stable Identifier

R-HSA-6797625

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Lipid phosphate phosphatase-related protein type 1, LPPR1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Lysosphingolipid and LPA receptors (Homo sapiens)
        
        LRPP4(LRPP1-3,5) hydrolyse LPA (Homo sapiens)
        
        LPPR4(LPPR1-3,5) [plasma membrane] (Homo sapiens)
        
        LPPR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TBJ4 PLPPR1

Gene Names

PLPPR1, LPPR1, PRG3

Chain

chain:1-325

Reference Genes

BioGPS Gene:54886 PLPPR1

COSMIC (genes):PLPPR1 PLPPR1

COSMIC (genes):PRG3 PLPPR1

CTD Gene:54886 PLPPR1

dbSNP Gene:54886 PLPPR1

ENSEMBL:ENSG00000148123 PLPPR1

HGNC:25993 PLPPR1

KEGG:hsa:54886 PLPPR1

Monarch:54886 PLPPR1

NCBI Gene:54886 PLPPR1

OMIM:619590 PLPPR1

UCSC:Q8TBJ4 PLPPR1

Reference Transcript

Other Identifiers

11726598_a_at

11726599_a_at

1570250_PM_at

1570250_at

17087615

219732_PM_at

219732_at

3182331

3182332

3182333

3182341

3182347

3182348

3182349

3182350

3182356

3182357

3182358

3182360

3182361

3182362

3182363

3182364

3182365

3182366

3182369

3182370

3182371

3182372

3182373

49989_at

54886

8156923

A_14_P104855

A_14_P111675

A_23_P259707

GE55437

GO:0003824

GO:0005515

GO:0005654

GO:0005886

GO:0006629

GO:0006644

GO:0007165

GO:0007399

GO:0008195

GO:0016020

GO:0016787

GO:0042995

GO:0043005

GO:0046839

GO:0048856

HMNXSV003049058

Hs2.382683.1.S1_3p_at

ILMN_1753026

ILMN_1780576

ILMN_2234930

PH_hs_0024356

TC09000515.hg

g8923280_3p_at

Participates

as a candidate of

LPPR4(LPPR1-3,5) [plasma membrane] (Homo sapiens)

Inferred To

LPPR1 [plasma membrane] (Dictyostelium discoideum)

Plppr1 [plasma membrane] (Mus musculus)

Plppr1 [plasma membrane] (Rattus norvegicus)

plpr-1 [plasma membrane] (Caenorhabditis elegans)

LPP1 [plasma membrane] (Saccharomyces cerevisiae)

DPP1 [plasma membrane] (Saccharomyces cerevisiae)

dpp1 [plasma membrane] (Schizosaccharomyces pombe)

plppr1 [plasma membrane] (Xenopus tropicalis)

Homologues of LPPR1 [plasma membrane] (Dictyostelium discoideum)

Homologues of LPPR1 [plasma membrane] (Saccharomyces cerevisiae)

PLPPR1 [plasma membrane] (Bos taurus)

PLPPR1 [plasma membrane] (Canis familiaris)

PLPPR1 [plasma membrane] (Gallus gallus)

PLPPR1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_060223.2, NP_997182.1

ENSEMBL

ENSP00000364008, ENST00000611695, ENSG00000276539, ENST00000374874, ENST00000614834, ENSP00000478338, ENSP00000477959, ENSG00000148123, ENST00000395056, ENSP00000378496

OpenTargets

ENSG00000148123

GeneCards

PLPPR1

HPA

ENSG00000148123-PLPPR1

PRO

Q8TBJ4

Pharos - Targets

Q8TBJ4

GlyGen

Q8TBJ4

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:O00186 STXBP3	4	p-Y521-STXBP3 [plasma membrane] (R-HSA-2263472) STXBP3 [plasma membrane] (R-HSA-2263473) p-STXBP3 [cytosol] (R-HSA-114680) STXBP3 [cytosol] (R-HSA-114682)	0.527	2
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.527	2
UniProt:P61224 RAP1B	2	RAP1B [plasma membrane] (R-HSA-377590) RAP1B [azurophil granule membrane] (R-HSA-6804972)	0.527	2

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