DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851

Stable Identifier
R-HSA-6790994
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851
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DIMT1 (DIMT1L) dimethylates the N(6) position of adenosine-1850 and adenosine-1851 of a precursor to 18S rRNA in the nucleolus (Zorbas et al. 2015). Dimethylation is observed on the 21S precursor and therefore occurs at this stage of rRNA processing or prior. Dimethylation of adenosine residues appears to occur after N(7)-methylation of guanosine-1639 by WBSCR22:TRMT112 (Zorbas et al. 2015). PNO1 is required for the methylation activity of DIMT1 (Zorbas et al. 2015). DIMT1 protein but not DIMT1 methylase activity is also required for efficient concomitant cleavage of 47S precursor rRNA at site A0 and site 1 (Zorbas et al. 2015).

Literature References
PubMed ID Title Journal Year
25851604 The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis

Zorbas, C, Nicolas, E, Wacheul, L, Huvelle, E, Heurgué-Hamard, V, Lafontaine, DL

Mol. Biol. Cell 2015
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
rRNA methylation (0031167)
Catalyst Activity
Catalyst Activity
Title
rRNA (adenine-N6,N6-)-dimethyltransferase activity of DIMT1 [nucleoplasm]
Physical Entity
DIMT1 [nucleoplasm]
Activity
rRNA (adenine-N6,N6-)-dimethyltransferase activity (0000179)
This event is regulated
Requirements
Authored
May, B  (2015-08-15)
Reviewed
Vincent, NG  (2016-01-30)
Sharma, S  (2016-02-12)
Created
May, B  (2015-08-16)