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OPRO [cytosol]
Stable Identifier
R-ALL-1247942
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
5-oxo-L-prolinate, 5-oxoproline, 5-oxo-L-proline
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
CHAC1,2 cleaves GSH to OPRO and CysGly (Bos taurus)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Bos taurus)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
OPRO [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Glutathione conjugation (Caenorhabditis elegans)
Glutathione synthesis and recycling (Caenorhabditis elegans)
CHAC1,2 cleaves GSH to OPRO and CysGly (Caenorhabditis elegans)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Caenorhabditis elegans)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
OPRO [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase II - Conjugation of compounds (Canis familiaris)
Glutathione conjugation (Canis familiaris)
Glutathione synthesis and recycling (Canis familiaris)
CHAC1,2 cleaves GSH to OPRO and CysGly (Canis familiaris)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Canis familiaris)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)
OPRO [cytosol]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase II - Conjugation of compounds (Danio rerio)
Glutathione conjugation (Danio rerio)
Glutathione synthesis and recycling (Danio rerio)
CHAC1,2 cleaves GSH to OPRO and CysGly (Danio rerio)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Danio rerio)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Danio rerio)
OPRO [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Glutathione conjugation (Dictyostelium discoideum)
Glutathione synthesis and recycling (Dictyostelium discoideum)
CHAC1,2 cleaves GSH to OPRO and CysGly (Dictyostelium discoideum)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)
OPRO [cytosol]
Metabolism (Drosophila melanogaster)
Biological oxidations (Drosophila melanogaster)
Phase II - Conjugation of compounds (Drosophila melanogaster)
Glutathione conjugation (Drosophila melanogaster)
Glutathione synthesis and recycling (Drosophila melanogaster)
CHAC1,2 cleaves GSH to OPRO and CysGly (Drosophila melanogaster)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Drosophila melanogaster)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)
OPRO [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase II - Conjugation of compounds (Gallus gallus)
Glutathione conjugation (Gallus gallus)
Glutathione synthesis and recycling (Gallus gallus)
CHAC1,2 cleaves GSH to OPRO and CysGly (Gallus gallus)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Gallus gallus)
OPRO [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Metabolic disorders of biological oxidation enzymes (Homo sapiens)
Defective OPLAH causes OPLAHD (Homo sapiens)
Defective OPLAH does not hydrolyse OPRO (Homo sapiens)
OPRO [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
CHAC1,2 cleaves GSH to OPRO and CysGly (Homo sapiens)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Homo sapiens)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)
OPRO [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase II - Conjugation of compounds (Mus musculus)
Glutathione conjugation (Mus musculus)
Glutathione synthesis and recycling (Mus musculus)
CHAC1,2 cleaves GSH to OPRO and CysGly (Mus musculus)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Mus musculus)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Mus musculus)
OPRO [cytosol]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase II - Conjugation of compounds (Rattus norvegicus)
Glutathione conjugation (Rattus norvegicus)
Glutathione synthesis and recycling (Rattus norvegicus)
CHAC1,2 cleaves GSH to OPRO and CysGly (Rattus norvegicus)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Rattus norvegicus)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)
OPRO [cytosol]
Metabolism (Saccharomyces cerevisiae)
Biological oxidations (Saccharomyces cerevisiae)
Phase II - Conjugation of compounds (Saccharomyces cerevisiae)
Glutathione conjugation (Saccharomyces cerevisiae)
Glutathione synthesis and recycling (Saccharomyces cerevisiae)
CHAC1,2 cleaves GSH to OPRO and CysGly (Saccharomyces cerevisiae)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)
OPRO [cytosol]
Metabolism (Schizosaccharomyces pombe)
Biological oxidations (Schizosaccharomyces pombe)
Phase II - Conjugation of compounds (Schizosaccharomyces pombe)
Glutathione conjugation (Schizosaccharomyces pombe)
Glutathione synthesis and recycling (Schizosaccharomyces pombe)
CHAC1,2 cleaves GSH to OPRO and CysGly (Schizosaccharomyces pombe)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)
OPRO [cytosol]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase II - Conjugation of compounds (Sus scrofa)
Glutathione conjugation (Sus scrofa)
Glutathione synthesis and recycling (Sus scrofa)
CHAC1,2 cleaves GSH to OPRO and CysGly (Sus scrofa)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Sus scrofa)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)
OPRO [cytosol]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase II - Conjugation of compounds (Xenopus tropicalis)
Glutathione conjugation (Xenopus tropicalis)
Glutathione synthesis and recycling (Xenopus tropicalis)
CHAC1,2 cleaves GSH to OPRO and CysGly (Xenopus tropicalis)
OPRO [cytosol]
GGCT transforms gGluCys to OPRO (Xenopus tropicalis)
OPRO [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)
OPRO [cytosol]
External Reference Information
External Reference
5-oxo-L-prolinate [ChEBI:58402]
Participates
as an input of
Defective OPLAH does not hydrolyse OPRO (Homo sapiens)
OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)
OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)
OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)
OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)
OPLAH hydrolyses OPRO to L-Glu (Danio rerio)
OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)
OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)
OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)
OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)
OPLAH hydrolyses OPRO to L-Glu (Mus musculus)
as an output of
CHAC1,2 cleaves GSH to OPRO and CysGly (Gallus gallus)
GGCT transforms gGluCys to OPRO (Gallus gallus)
CHAC1,2 cleaves GSH to OPRO and CysGly (Saccharomyces cerevisiae)
CHAC1,2 cleaves GSH to OPRO and CysGly (Schizosaccharomyces pombe)
CHAC1,2 cleaves GSH to OPRO and CysGly (Dictyostelium discoideum)
GGCT transforms gGluCys to OPRO (Caenorhabditis elegans)
CHAC1,2 cleaves GSH to OPRO and CysGly (Caenorhabditis elegans)
GGCT transforms gGluCys to OPRO (Drosophila melanogaster)
CHAC1,2 cleaves GSH to OPRO and CysGly (Drosophila melanogaster)
GGCT transforms gGluCys to OPRO (Xenopus tropicalis)
CHAC1,2 cleaves GSH to OPRO and CysGly (Xenopus tropicalis)
CHAC1,2 cleaves GSH to OPRO and CysGly (Danio rerio)
GGCT transforms gGluCys to OPRO (Danio rerio)
GGCT transforms gGluCys to OPRO (Sus scrofa)
CHAC1,2 cleaves GSH to OPRO and CysGly (Sus scrofa)
CHAC1,2 cleaves GSH to OPRO and CysGly (Bos taurus)
GGCT transforms gGluCys to OPRO (Bos taurus)
GGCT transforms gGluCys to OPRO (Canis familiaris)
CHAC1,2 cleaves GSH to OPRO and CysGly (Canis familiaris)
CHAC1,2 cleaves GSH to OPRO and CysGly (Rattus norvegicus)
GGCT transforms gGluCys to OPRO (Rattus norvegicus)
GGCT transforms gGluCys to OPRO (Homo sapiens)
GGCT transforms gGluCys to OPRO (Mus musculus)
CHAC1,2 cleaves GSH to OPRO and CysGly (Mus musculus)
CHAC1,2 cleaves GSH to OPRO and CysGly (Homo sapiens)
Cross References
ZINC
ZINC000003598263
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