Reactome | IFNGR2 [plasma membrane]

IFNGR2 [plasma membrane]

Stable Identifier

R-CFA-629620

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

IFNGR2, A0A8I3QCJ0

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Interferon Signaling (Canis familiaris)
    - Interferon gamma signaling (Canis familiaris)
      - Binding of STAT1 to p-IFNGR1 (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - IFNG dimer binds IFNGR (Canis familiaris)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - IFNG signaling activates MAPKs (Canis familiaris)
        
        Activated JAK1 binds RAF1 (Canis familiaris)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        JAK1-mediated phosphorylation of RAF1 (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Canis familiaris)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        IFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitors [plasma membrane] (Canis familiaris)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - JAK2-activated MAPKs phosphorylate YBX1 (Canis familiaris)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - Phosphorylation of IFNGR1 by JAK kinases (Canis familiaris)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - Phosphorylation of JAK2 (Canis familiaris)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - Phosphorylation of STAT1 at Ser727 (Canis familiaris)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - Phosphorylation of STAT1 by JAK kinases (Canis familiaris)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - Regulation of IFNG signaling (Canis familiaris)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Canis familiaris)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Canis familiaris)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - Release of STAT1 dimer from active receptor unit (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
      - Transphosphorylation of JAK1 (Canis familiaris)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Canis familiaris)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK [plasma membrane] (Canis familiaris)
        
        IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR2 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3QCJ0

Gene Names

IFNGR2

Reference Genes

ENSEMBL:ENSCAFG00845026979.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026979.1 IFNGR2

Other Identifiers

487739

Cfa.14847.1.A1_s_at

Cfa.4899.1.A1_x_at

CfaAffx.14354.1.S1_at

GO:0005515

GO:0016020

Participates

as a component of

Inferred From

IFNGR2 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000159128

Ensembl

ENSCAFT00845047522, ENSCAFG00845026979, ENSCAFP00845037288

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