Reactome | IFNGR2 [plasma membrane]

IFNGR2 [plasma membrane]

Stable Identifier

R-GGA-629620

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

IFNGR2, A0A1D5PS87

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Cytokine Signaling in Immune system (Gallus gallus)
  - Interferon Signaling (Gallus gallus)
    - Interferon gamma signaling (Gallus gallus)
      - Binding of STAT1 to p-IFNGR1 (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - IFNG dimer binds IFNGR (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - IFNG signaling activates MAPKs (Gallus gallus)
        
        Activated JAK1 binds RAF1 (Gallus gallus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR complex with p-JAK [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        JAK1-activated RAF1 phosphorylates MAPKs (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        JAK1-mediated phosphorylation of RAF1 (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Gallus gallus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        IFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitors [plasma membrane] (Gallus gallus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - JAK2-activated MAPKs phosphorylate YBX1 (Gallus gallus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR complex with p-JAK [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - Phosphorylation of IFNGR1 by JAK kinases (Gallus gallus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR complex with p-JAK [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - Phosphorylation of JAK2 (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - Phosphorylation of STAT1 at Ser727 (Gallus gallus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - Phosphorylation of STAT1 by JAK kinases (Gallus gallus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - Regulation of IFNG signaling (Gallus gallus)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - Release of STAT1 dimer from active receptor unit (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Gallus gallus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
      - Transphosphorylation of JAK1 (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR complex with p-JAK [plasma membrane] (Gallus gallus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Gallus gallus)
        
        IFNGR2 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5PS87

Gene Names

IFNGR2

Reference Genes

ENSEMBL:ENSGALG00000032660

ENSEMBL:ENSGALG00010012077.1 IFNGR2

Other Identifiers

418502

GO:0004896

GO:0005515

GO:0019221

GO:0023052

GO:0060089

GT_A_87_P014429

GT_A_87_P133303

GT_A_87_P196433

Gga.7296.1.S1_at

Gga.7296.2.S1_a_at

Gga.7296.3.S1_s_at

Participates

as a component of

Inferred From

IFNGR2 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000159128

Ensembl

ENSGALT00010028938, ENSGALP00010016697, ENSGALG00010012077

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