Reactome | DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate

DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate

Stable Identifier

R-HSA-5694018

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate

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The last step in the glycine cleavage system is the reoxidation of the reduced lipoate (dihydrolipoyl group) attached to the H protein (GCSH:DHLL) catalysed by the L protein (mitochondrial dihydrolipoyl dehydrogenase, DLD) (Harris et al. 1997, Ciszak et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
9242632	Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex. Harris, RA, Bowker-Kinley, MM, Wu, P, Jeng, J, Popov, KM	J Biol Chem	1997
16263718	How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex Ciszak, EM, Makal, A, Hong, YS, Vettaikkorumakankauv, AK, Korotchkina, LG, Patel, MS	J. Biol. Chem.	2006