Reactome | UCH proteinases

UCH proteinases

Stable Identifier

R-HSA-5689603

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin (Larsen et al. 1998), and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains (Misaghi et al. 2009, Lam et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
16325574	A genomic and functional inventory of deubiquitinating enzymes Sixma, TK, Luna-Vargas, MP, Nijman, SM, Velds, A, Brummelkamp, TR, Bernards, R, Dirac, AM	Cell	2005
19243136	Polyubiquitin binding and disassembly by deubiquitinating enzymes Reyes-Turcu, FE, Wilkinson, KD	Chem. Rev.	2009