Reactome | BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1

BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1

Stable Identifier

R-HSA-5690759

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1

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BRCA1 associated protein 1 (BAP1) is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway (Murali et al. 2013). BAP1 mediates the deubiquitination of Host cell factor 1 (HCFC1) thereby regulating cell growth (Eletr & Wilinson 2011), though deubiquitination of HCFC1 does not lead to increased HCFC1 stability. HCFC1 is K48 and K63 ubiquitinated; the major site of linkage are lysines 1807 and 1808 (Machida et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19815555	The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1 Machida, YJ, Machida, Y, Vashisht, AA, Wohlschlegel, JA, Dutta, A	J. Biol. Chem.	2009