BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1

Stable Identifier
R-HSA-5690759
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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BRCA1 associated protein 1 (BAP1) is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway (Murali et al. 2013). BAP1 mediates the deubiquitination of Host cell factor 1 (HCFC1) thereby regulating cell growth (Eletr & Wilinson 2011), though deubiquitination of HCFC1 does not lead to increased HCFC1 stability. HCFC1 is K48 and K63 ubiquitinated; the major site of linkage are lysines 1807 and 1808 (Machida et al. 2009).

Literature References
PubMed ID Title Journal Year
19815555 The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1

Machida, YJ, Machida, Y, Vashisht, AA, Wohlschlegel, JA, Dutta, A

J. Biol. Chem. 2009
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hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of BAP1:K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created