Reactome | ADRM1 binds 26S proteasome

ADRM1 binds 26S proteasome

Stable Identifier

R-HSA-5665871

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ADRM1 (also called Rpn13) interacts with the 26S proteasome base unit PRDM1 (Rpn2) via its amino-terminus and is found in the majority of 26S proteasomes. It is a receptor for Ubiquitin (Ub) that can bind K48-linked di-Ub (Schreiner et al. 2008, Husnjak et al. 2008) and de-ubiquitinating enzymes (DUBs) such as PSMD14 (Rpn11, POH1), USP14, and UCHL5 (UCH37) (Reyes-Turcu et al., 2009). Together, these DUBs disassemble poly-Ub chains and recycle ubiquitin during proteasomal degradation.

Literature References

PubMed ID	Title	Journal	Year
18497827	Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction Elsasser, S, Schreiner, P, Randles, L, Zhang, N, Finley, D, Chen, X, Groll, M, Husnjak, K, Walters, KJ, Dikic, I	Nature	2008