Reactome | BAP1 binds Ub-HCFC1

BAP1 binds Ub-HCFC1

Stable Identifier

R-HSA-5690785

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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BRCA1 associated protein 1 (BAP1) is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway (Eletr & Wilkinson 2011, Murali et al. 2013). BAP1 mediates the deubiquitination of Host cell factor 1 (HCFC1) thereby regulating cell growth, though deubiquitination of HCFC1 does not lead to increased HCFC1 stability. HCFC1 is K48 and K63 ubiquitinated. The major site of linkage are lysines 1807 and 1808 (Machida et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19188440	Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1 Misaghi, S, Ottosen, S, Izrael-Tomasevic, A, Arnott, D, Lamkanfi, M, Lee, J, Liu, J, O'Rourke, K, Dixit, VM, Wilson, AC	Mol. Cell. Biol.	2009