Reactome | WHSC1 dimethylates histone H4 on lysine K21 at DSBs

WHSC1 dimethylates histone H4 on lysine K21 at DSBs

Stable Identifier

R-HSA-5682965

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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WHSC1 dimethylates histone H4 on lysine K21 at DSBs

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WHSC1 (MMSET) histone methyltransferase dimethylates histone H4 (HIST1H4A) on lysine residue K21 (commonly labeled in literature as K20), locally increasing the concentration of the H4K20Me2 mark. H4K20Me2 (Me2-K21-HIST1H4A) serves as a binding site for TP53BP1 (53BP1). The recruitment of WHSC1 to DNA double-strand breaks (DSBs) is independent of RNF8 and RNF168, but the catalytic activity of all three proteins is necessary for binding and accumulation of TP53BP1 at DSBs (Pei et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21293379	MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites Pei, H, Zhang, L, Luo, K, Qin, Y, Chesi, M, Fei, F, Bergsagel, PL, Wang, L, You, Z, Lou, Z	Nature	2011