AKR1A1 reduces D-glucuronate to L-gulonate

Stable Identifier
R-HSA-5661256
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
D-glucuronate + NADPH + H+ => L-gulonate + NADP+
ReviewStatus
5/5
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AKR1A1 reduces D-glucuronate to L-gulonate
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Cytosolic AKR1A1 (Aldo-keto reductase family 1 member A1) catalyzes the reduction by NADPH of D-glucuronate to L-gulonate (Barski et al. 1995).
Literature References
PubMed ID Title Journal Year
7669785 Mechanism of human aldehyde reductase: characterization of the active site pocket

Barski, OA, Gabbay, KH, Grimshaw, CE, Bohren, KM

Biochemistry 1995
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Catalyst Activity

L-glucuronate reductase activity of AKR1A1 [cytosol]

Physical Entity
AKR1A1 [cytosol] (Homo sapiens)
Activity
L-glucuronate reductase activity (GO:0047939)
Orthologous Events
AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)
AKR1A1 reduces D-glucuronate to L-gulonate (Canis familiaris)
AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)
AKR1A1 reduces D-glucuronate to L-gulonate (Dictyostelium discoideum)
AKR1A1 reduces D-glucuronate to L-gulonate (Drosophila melanogaster)
AKR1A1 reduces D-glucuronate to L-gulonate (Gallus gallus)
AKR1A1 reduces D-glucuronate to L-gulonate (Mus musculus)
AKR1A1 reduces D-glucuronate to L-gulonate (Rattus norvegicus)
AKR1A1 reduces D-glucuronate to L-gulonate (Saccharomyces cerevisiae)
AKR1A1 reduces D-glucuronate to L-gulonate (Schizosaccharomyces pombe)
AKR1A1 reduces D-glucuronate to L-gulonate (Sus scrofa)
AKR1A1 reduces D-glucuronate to L-gulonate (Xenopus tropicalis)
Authored
D'Eustachio, P  (2015-08-14)
Reviewed
Jassal, B  (2015-08-14)
Created
D'Eustachio, P  (2015-01-10)
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