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AKR1A1 [cytosol]
Stable Identifier
R-HSA-5661253
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Aldo-keto reductase family 1 member A1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Homo sapiens)
AKR1A1 [cytosol] (Homo sapiens)
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Formation of xylulose-5-phosphate (Homo sapiens)
AKR1A1 reduces D-glucuronate to L-gulonate (Homo sapiens)
AKR1A1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14550 AKR1A1
Gene Names
AKR1A1, ALDR1, ALR
Chain
initiator methionine:, chain:2-325
Reference Genes
BioGPS Gene:10327 AKR1A1
COSMIC (genes):AKR1A1 AKR1A1
CTD Gene:10327 AKR1A1
dbSNP Gene:10327 AKR1A1
ENSEMBL:ENSG00000117448 AKR1A1
HGNC:380 AKR1A1
KEGG:hsa:10327 AKR1A1
Monarch:10327 AKR1A1
NCBI Gene:10327 AKR1A1
OMIM:103830 AKR1A1
UCSC:P14550 AKR1A1
Reference Transcript
RefSeq:NM_001202413.2 AKR1A1
RefSeq:NM_001202414.2 AKR1A1
RefSeq:NM_006066.4 AKR1A1
RefSeq:NM_153326.3 AKR1A1
Other Identifiers
10327
11716509_a_at
16664100
201900_PM_s_at
201900_s_at
2334375
2334376
2334377
2334381
2334382
2334384
2334385
2334386
2334387
2334388
2334389
2334390
2334391
2334392
2334393
2334394
2334395
2334396
2334397
2334398
2334399
2334400
2334401
38780_at
7901110
A_24_P79750
A_24_P79755
GE57517
GO:0003824
GO:0004032
GO:0004033
GO:0005515
GO:0005615
GO:0005737
GO:0005829
GO:0005886
GO:0006629
GO:0006790
GO:0008106
GO:0016324
GO:0016491
GO:0019640
GO:0042840
GO:0043066
GO:0043226
GO:0044597
GO:0044598
GO:0045202
GO:0046185
GO:0047655
GO:0047939
GO:0047941
GO:0047956
GO:0070062
GO:0080007
GO:0098754
GO:0110095
GO:0160163
GO:1901135
GO:1901687
GO:1990002
HMNXSV003056244
ILMN_1728047
ILMN_1774938
ILMN_2380771
J04794_at
PH_hs_0024208
TC01000574.hg
g5174390_3p_a_at
Inferred To
exc-15 [cytosol]
(Caenorhabditis elegans)
Akr2E3 [cytosol]
(Drosophila melanogaster)
akr1a1 [cytosol]
(Xenopus tropicalis)
alrC [cytosol]
(Dictyostelium discoideum)
Akr1a1 [cytosol]
(Mus musculus)
Akr1a1 [cytosol]
(Rattus norvegicus)
Dmel\CG9436 [cytosol]
(Drosophila melanogaster)
Dmel\CG6083 [cytosol]
(Drosophila melanogaster)
Ar2 [cytosol]
(Drosophila melanogaster)
Dmel\CG12766 [cytosol]
(Drosophila melanogaster)
AKR1A1 [cytosol]
(Bos taurus)
AKR1A1 [cytosol]
(Caenorhabditis elegans)
AKR1A1 [cytosol]
(Canis familiaris)
AKR1A1 [cytosol]
(Dictyostelium discoideum)
AKR1A1 [cytosol]
(Gallus gallus)
AKR1A1 [cytosol]
(Saccharomyces cerevisiae)
AKR1A1 [cytosol]
(Schizosaccharomyces pombe)
AKR1A1 [cytosol]
(Sus scrofa)
ARA1 [cytosol]
(Saccharomyces cerevisiae)
Akr1B [cytosol]
(Drosophila melanogaster)
Homologues of AKR1A1 [cytosol]
(Caenorhabditis elegans)
Homologues of AKR1A1 [cytosol]
(Dictyostelium discoideum)
Homologues of AKR1A1 [cytosol]
(Drosophila melanogaster)
Homologues of AKR1A1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of AKR1A1 [cytosol]
(Schizosaccharomyces pombe)
alrA [cytosol]
(Dictyostelium discoideum)
alrB [cytosol]
(Dictyostelium discoideum)
ARY [cytosol]
(Drosophila melanogaster)
akr1a1b [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_006057.1
,
NP_697021.1
,
NP_001189343.1
,
NP_001189342.1
ZINC - World Drugs
AK1A1_HUMAN
ENSEMBL
ENSG00000117448
,
ENST00000621846
,
ENST00000372070
,
ENSP00000480713
,
ENSP00000361140
,
ENST00000351829
,
ENSP00000312606
OpenTargets
ENSG00000117448
ZINC - Substances
AK1A1_HUMAN
ZINC target
P14550
PRO
P14550
GlyGen
P14550
PDB
2ALR
ZINC - Investigational
AK1A1_HUMAN
IntEnz
1.1.1.54
GeneCards
AKR1A1
HPA
ENSG00000117448-AKR1A1
Pharos - Targets
P14550
ZINC - Predictions - Purchasable
AK1A1_HUMAN
HMDB Protein
HMDBP00507
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:Q9NYB0 TERF2IP
1
TERF2IP [nucleoplasm]
(R-HSA-174873)
0.508
2
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