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Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane]
Stable Identifier
R-HSA-5654330
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Participants
components
Activated FGFR4:p-FRS2 [plasma membrane]
(Homo sapiens)
p-Y542,Y580-PTPN11 [cytosol]
(Homo sapiens)
Participates
as a component of
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
as an input of
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Inferred To
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane]
(Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane]
(Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane]
(Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane]
(Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane]
(Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane]
(Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane]
(Sus scrofa)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane]
(Xenopus tropicalis)
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