Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

Stable Identifier
R-HSA-5654667
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
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p-PPTN11 recruits GRB2-GAB1 to the activated receptor.

Literature References
PubMed ID Title Journal Year
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Schlessinger, J, Kouhara, H, Lax, I, Hadari, YR

Mol Cell Biol 1998
11353842 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

Ong, SH, Schlessinger, J, Lax, I, Gotoh, N, Hadari, YR, Guy, GR

Proc Natl Acad Sci U S A 2001
9299490 SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells

Lim, YP, Low, BC, Ong, SH, Guy, GR

Biochem Biophys Res Commun 1997
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Podolsky, DK, Goke, M, Tsunekawa, S, Kanai, M

J Biol Chem 1997
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Orthologous Events
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-06)
Created
Rothfels, K  (2014-12-03)
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