Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

Stable Identifier
Reaction [binding]
Homo sapiens
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p-PPTN11 recruits GRB2-GAB1 to the activated receptor.

Literature References
PubMed ID Title Journal Year
11353842 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

Ong, SH, Hadari, YR, Gotoh, N, Guy, GR, Schlessinger, J, Lax, I

Proc Natl Acad Sci U S A 2001
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J

Mol Cell Biol 1998
9299490 SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells

Ong, SH, Lim, YP, Low, BC, Guy, GR

Biochem Biophys Res Commun 1997
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Kanai, M, Goke, M, Tsunekawa, S, Podolsky, DK

J Biol Chem 1997
Participant Of
Orthologous Events
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