Reactome | FEN1 bound to POLB cleaves displaced DNA strand (flap)

FEN1 bound to POLB cleaves displaced DNA strand (flap)

Stable Identifier

R-HSA-5651782

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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FEN1 bound to POLB cleaves displaced DNA strand (flap)

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POLB-bound FEN1 (flap endonuclease) cleaves the displaced DNA strand (flap structure), which contains the damaged AP residue that could not be excised by POLB (DNA polymerase beta) (Klungland and Lindahl 1997, Prasad et al. 2001, Liu et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15561706	DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair Liu, Y, Beard, WA, Shock, DD, Prasad, R, Hou, EW, Wilson, SH	J. Biol. Chem.	2005
11440997	DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis Prasad, R, Lavrik, OI, Kim, SJ, Kedar, P, Yang, XP, Vande Berg, BJ, Wilson, SH	J. Biol. Chem.	2001
9214649	Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). Klungland, A, Lindahl, T	EMBO J	1997