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PARP1,PARP2 dimers [nucleoplasm]
Stable Identifier
R-HSA-5649884
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Homodimers and/or heterodimers of PARP1 and PARP2
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)
PARG dePARylates PARP1,PARP2 (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
POLB-mediated DNA strand displacement synthesis (Homo sapiens)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers [nucleoplasm] (Homo sapiens)
Participants
components
x 2
PARP1,PARP2 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
PARG dePARylates PARP1,PARP2 (Homo sapiens)
as an input of
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)
PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)
as a component of
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
Inferred To
PARP1,PARP2 dimers [nucleoplasm]
(Bos taurus)
PARP1,PARP2 dimers [nucleoplasm]
(Caenorhabditis elegans)
PARP1,PARP2 dimers [nucleoplasm]
(Canis familiaris)
PARP1,PARP2 dimers [nucleoplasm]
(Danio rerio)
PARP1,PARP2 dimers [nucleoplasm]
(Dictyostelium discoideum)
PARP1,PARP2 dimers [nucleoplasm]
(Drosophila melanogaster)
PARP1,PARP2 dimers [nucleoplasm]
(Gallus gallus)
PARP1,PARP2 dimers [nucleoplasm]
(Mus musculus)
PARP1,PARP2 dimers [nucleoplasm]
(Plasmodium falciparum)
PARP1,PARP2 dimers [nucleoplasm]
(Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm]
(Sus scrofa)
PARP1,PARP2 dimers [nucleoplasm]
(Xenopus tropicalis)
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