PARP1 or PARP2 binds DDB2 at GG-NER site

Stable Identifier
R-HSA-5696664
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PARP1 (or PARP2) is recruited to global genomic nucleotide excision repair (GG-NER) site through interaction with DDB2 and, probably, distorted single strand DNA (Pines et al. 2012, Robu et al. 2013).

Literature References
PubMed ID Title Journal Year
23045548 PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

Pines, A, Vrouwe, MG, Marteijn, JA, Typas, D, Luijsterburg, MS, Cansoy, M, Hensbergen, P, Deelder, A, de Groot, A, Matsumoto, S, Sugasawa, K, Thoma, N, Vermeulen, W, Vrieling, H, Mullenders, L

J. Cell Biol. 2012
23319653 Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair

Robu, M, Shah, RG, Petitclerc, N, Brind'Amour, J, Kandan-Kulangara, F, Shah, GM

Proc. Natl. Acad. Sci. U.S.A. 2013
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