Reactome | PARG dePARylates PARP1,PARP2

PARG dePARylates PARP1,PARP2

Stable Identifier

R-HSA-5651828

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PARG acts as a poly(ADP-ribosyl)glycohydrolase (PAR glycohydrolase) that reverses auto(ADP-ribosyl)ation of PARP1 and/or PARP2 (Kim et al. 2004). PARG activity is required for the turnover of PARP1 and/or PARP2, which allows for the rapid completion of the single strand break (SSB) repair (Fisher et al. 2007). PARG may be recruited to DNA damage site through PCNA binding (Mortusewicz et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
17548475	Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase Hochegger, H, Takeda, S, Fisher, AE, Caldecott, KW	Mol. Cell. Biol.	2007
21398629	PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms Amé, JC, Mortusewicz, O, Leonhardt, H, Schreiber, V, Fouquerel, E	Nucleic Acids Res.	2011
15607977	NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1 Kraus, WL, Mauro, S, Lis, JT, Kim, MY, Gévry, N	Cell	2004