PARG dePARylates PARP1,PARP2

Stable Identifier
R-HSA-5651828
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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General
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PARG acts as a poly(ADP-ribosyl)glycohydrolase (PAR glycohydrolase) that reverses auto(ADP-ribosyl)ation of PARP1 and/or PARP2 (Kim et al. 2004). PARG activity is required for the turnover of PARP1 and/or PARP2, which allows for the rapid completion of the single strand break (SSB) repair (Fisher et al. 2007). PARG may be recruited to DNA damage site through PCNA binding (Mortusewicz et al. 2011).
Literature References
PubMed ID Title Journal Year
17548475 Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase

Hochegger, H, Takeda, S, Fisher, AE, Caldecott, KW

Mol. Cell. Biol. 2007
21398629 PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

Amé, JC, Mortusewicz, O, Leonhardt, H, Schreiber, V, Fouquerel, E

Nucleic Acids Res. 2011
15607977 NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1

Kraus, WL, Mauro, S, Lis, JT, Kim, MY, Gévry, N

Cell 2004
Participants
Participates
Catalyst Activity

poly(ADP-ribose) glycohydrolase activity of PARG [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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