PARG dePARylates PARP1,PARP2

Stable Identifier
R-HSA-5651828
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PARG acts as a poly(ADP-ribosyl)glycohydrolase (PAR glycohydrolase) that reverses auto(ADP-ribosyl)ation of PARP1 and/or PARP2 (Kim et al. 2004). PARG activity is required for the turnover of PARP1 and/or PARP2, which allows for the rapid completion of the single strand break (SSB) repair (Fisher et al. 2007). PARG may be recruited to DNA damage site through PCNA binding (Mortusewicz et al. 2011).

Literature References
PubMed ID Title Journal Year
21398629 PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

Mortusewicz, O, Fouquerel, E, Amé, JC, Leonhardt, H, Schreiber, V

Nucleic Acids Res. 2011
17548475 Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase

Fisher, AE, Hochegger, H, Takeda, S, Caldecott, KW

Mol. Cell. Biol. 2007
15607977 NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1

Kim, MY, Mauro, S, Gévry, N, Lis, JT, Kraus, WL

Cell 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
poly(ADP-ribose) glycohydrolase activity of PARG [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created