NEIL2 recognizes and binds 5-OHU-dsDNA

Stable Identifier
R-HSA-5649686
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NEIL2 (endonuclease 8-like protein 2), an enzyme with a dual DNA glysocylase and beta/delta lyase activity, recognizes 5-hydroxyuracil (5-OHU) created by DNA damaging oxidation of cytosine (Hazra et al. 2002).

Literature References
PubMed ID Title Journal Year
12097317 Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

Hazra, TK, Kow, YW, Hatahet, Z, Imhoff, B, Boldogh, I, Mokkapati, SK, Mitra, S, Izumi, T

J. Biol. Chem. 2002
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