NEIL2 recognizes and binds 5-OHU-dsDNA

Stable Identifier
R-HSA-5649686
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL2 recognizes and binds 5-OHU-dsDNA
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NEIL2 (endonuclease 8-like protein 2), an enzyme with a dual DNA glysocylase and beta/delta lyase activity, recognizes 5-hydroxyuracil (5-OHU) created by DNA damaging oxidation of cytosine (Hazra et al. 2002).
Literature References
PubMed ID Title Journal Year
12097317 Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

Mokkapati, SK, Imhoff, B, Kow, YW, Mitra, S, Izumi, T, Hazra, TK, Hatahet, Z, Boldogh, I

J. Biol. Chem. 2002
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Authored
Orlic-Milacic, M  (2014-12-04)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Orlic-Milacic, M  (2014-11-21)
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