Reactome | p-T718-PKN3 [cytosol]

p-T718-PKN3 [cytosol]

Stable Identifier

R-HSA-5623654

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T718-PRK3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)
        
        p-T774-PKN1,p-T816-PKN2,p-T718-PKN3 [cytosol] (Homo sapiens)
        
        p-T718-PKN3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6P5Z2 PKN3

Gene Names

PKN3, PKNBETA

Chain

chain:1-889

Reference Genes

BioGPS Gene:29941 PKN3

COSMIC (genes):PKN3 PKN3

CTD Gene:29941 PKN3

dbSNP Gene:29941 PKN3

ENSEMBL:ENSG00000160447 PKN3

ENSEMBL:ENSG00000160447.7 PKN3

HGNC:17999 PKN3

KEGG Gene (Homo sapiens):29941 PKN3

Monarch:29941 PKN3

NCBI Gene:29941 PKN3

OMIM:610714 PKN3

UCSC:Q6P5Z2 PKN3

Reference Transcript

RefSeq:NM_013355.4 PKN3

Other Identifiers

11722938_a_at

11722939_a_at

17089819

226299_PM_at

226299_at

29941

3190684

3190685

3190686

3190688

3190689

3190690

3190691

3190692

3190693

3190694

3190696

3190697

3190698

3190699

3190700

3190701

3190702

3190705

3190707

3190708

3190709

3190710

3190711

3190713

3190714

3190715

3190717

3190718

3190719

55643_at

64669_at

8158380

85649_at

A_23_P258982

A_33_P3220202

GE53516

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0004698

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005794

GO:0005829

GO:0006468

GO:0007165

GO:0010631

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0023052

GO:0031267

GO:0035556

GO:0036211

GO:0043226

GO:0048471

GO:0048870

GO:0106310

GO:0140096

HMNXSV003009119

Hs.44101.0.S1_3p_at

ILMN_1797184

PH_hs_0028145

TC09000699.hg

Participates

as a candidate of

p-T774-PKN1,p-T816-PKN2,p-T718-PKN3 [cytosol] (Homo sapiens)

Other forms of this molecule

PKN3 [cytosol]

Inferred To

phospho-PKN3 [cytosol] (Gallus gallus)

Homologues of p-T718-PKN3 [cytosol] (Caenorhabditis elegans)

Homologues of p-T718-PKN3 [cytosol] (Danio rerio)

Homologues of p-T718-PKN3 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T718-PKN3 [cytosol] (Bos taurus)

phospho-p-T718-PKN3 [cytosol] (Caenorhabditis elegans)

phospho-p-T718-PKN3 [cytosol] (Canis familiaris)

phospho-p-T718-PKN3 [cytosol] (Danio rerio)

phospho-p-T718-PKN3 [cytosol] (Drosophila melanogaster)

phospho-p-T718-PKN3 [cytosol] (Mus musculus)

phospho-p-T718-PKN3 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T718-PKN3 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T718-PKN3 [cytosol] (Sus scrofa)

phospho-p-T718-PKN3 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 718

Coordinate

718

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_037487.2

Guide to Pharmacology - Targets

1522

OpenTargets

ENSG00000160447

IntEnz

2.7.11.13

GeneCards

Q6P5Z2

HPA

ENSG00000160447-PKN3

Ensembl

ENSG00000160447, ENSP00000291906, ENST00000291906

PRO

Q6P5Z2

Pharos - Targets

Q6P5Z2

HMDB Protein

HMDBP09509

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A1A4S6 ARHGAP10	1	ARHGAP10 [cytosol] (R-HSA-195125)	0.681	5
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q22038	12	RHOD [mitochondrial outer membrane] (R-CEL-9693212) RHOD [cytosol] (R-CEL-194848) RHOD [plasma membrane] (R-CEL-194889) RHOD [Golgi membrane] (R-CEL-9693236) RHOA [ficolin-1-rich granule membrane] (R-CEL-6804971) RHOF [plasma membrane] (R-CEL-194921) RHOF [secretory granule membrane] (R-CEL-6804978) RHOA [secretory granule membrane] (R-CEL-6804980) RHOA [endoplasmic reticulum membrane] (R-CEL-5672082) RHOD [endosome membrane] (R-CEL-5666090) RHOA [cytosol] (R-CEL-194866) RHOA [plasma membrane] (R-CEL-194510)	0.544	2

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