Reactome | VxPx cargo-targeting to cilium

VxPx cargo-targeting to cilium

Stable Identifier

R-HSA-5620916

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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A number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of these cargo to the cilium (Mazelova et al, 2009; Geng et al, 2006; Jenkins et al, 2006; Ward et al, 2011; reviewed in Deretic, 2013). Although there is some support for the presence of a VxPx or related motif in the C-terminal tail of cargo destined for ARF4-mediated transport to the cilium, the details of this have not been definitively established and other ciliary targeting sequences have also been identified (reviewed in Deretic, 2013; Bhogaraju et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
19153612	Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4 Mazelova, J, Astuto-Gribble, L, Inoue, H, Tam, BM, Schonteich, E, Prekeris, R, Moritz, OL, Randazzo, PA, Deretic, D	EMBO J.	2009
16537653	Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif Geng, L, Okuhara, D, Yu, Z, Tian, X, Cai, Y, Shibazaki, S, Somlo, S	J. Cell. Sci.	2006
23945166	Intraflagellar transport complex structure and cargo interactions Bhogaraju, S, Engel, BD, Lorentzen, E	Cilia	2013
16782012	Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17 Jenkins, PM, Hurd, TW, Zhang, L, McEwen, DP, Brown, RL, Margolis, B, Verhey, KJ, Martens, JR	Curr. Biol.	2006
23567335	Crosstalk of Arf and Rab GTPases en route to cilia Deretic, D	Small GTPases	2013
21775626	A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1 Ward, HH, Brown-Glaberman, U, Wang, J, Morita, Y, Alper, SL, Bedrick, EJ, Gattone, VH, Deretic, D, Wandinger-Ness, A	Mol. Biol. Cell	2011