A number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of these cargo to the cilium (Mazelova et al, 2009; Geng et al, 2006; Jenkins et al, 2006; Ward et al, 2011; reviewed in Deretic, 2013). Although there is some support for the presence of a VxPx or related motif in the C-terminal tail of cargo destined for ARF4-mediated transport to the cilium, the details of this have not been definitively established and other ciliary targeting sequences have also been identified (reviewed in Deretic, 2013; Bhogaraju et al, 2013).
Deretic, D, Schonteich, E, Inoue, H, Mazelova, J, Prekeris, R, Astuto-Gribble, L, Moritz, OL, Randazzo, PA, Tam, BM
Somlo, S, Shibazaki, S, Cai, Y, Tian, X, Yu, Z, Geng, L, Okuhara, D
Bhogaraju, S, Engel, BD, Lorentzen, E
Zhang, L, Hurd, TW, Martens, JR, Brown, RL, Jenkins, PM, Verhey, KJ, McEwen, DP, Margolis, B
Deretic, D
Alper, SL, Deretic, D, Brown-Glaberman, U, Wandinger-Ness, A, Morita, Y, Ward, HH, Bedrick, EJ, Wang, J, Gattone, VH
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