VxPx cargo-targeting to cilium

Stable Identifier
Homo sapiens
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A number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of these cargo to the cilium (Mazelova et al, 2009; Geng et al, 2006; Jenkins et al, 2006; Ward et al, 2011; reviewed in Deretic, 2013). Although there is some support for the presence of a VxPx or related motif in the C-terminal tail of cargo destined for ARF4-mediated transport to the cilium, the details of this have not been definitively established and other ciliary targeting sequences have also been identified (reviewed in Deretic, 2013; Bhogaraju et al, 2013).
Literature References
PubMed ID Title Journal Year
19153612 Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

Deretic, D, Schonteich, E, Inoue, H, Mazelova, J, Prekeris, R, Astuto-Gribble, L, Moritz, OL, Randazzo, PA, Tam, BM

EMBO J. 2009
16537653 Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

Somlo, S, Shibazaki, S, Cai, Y, Tian, X, Yu, Z, Geng, L, Okuhara, D

J. Cell. Sci. 2006
23945166 Intraflagellar transport complex structure and cargo interactions

Bhogaraju, S, Engel, BD, Lorentzen, E

Cilia 2013
16782012 Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17

Zhang, L, Hurd, TW, Martens, JR, Brown, RL, Jenkins, PM, Verhey, KJ, McEwen, DP, Margolis, B

Curr. Biol. 2006
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
21775626 A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1

Alper, SL, Deretic, D, Brown-Glaberman, U, Wandinger-Ness, A, Morita, Y, Ward, HH, Bedrick, EJ, Wang, J, Gattone, VH

Mol. Biol. Cell 2011
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