A number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of these cargo to the cilium (Mazelova et al, 2009; Geng et al, 2006; Jenkins et al, 2006; Ward et al, 2011; reviewed in Deretic, 2013). Although there is some support for the presence of a VxPx or related motif in the C-terminal tail of cargo destined for ARF4-mediated transport to the cilium, the details of this have not been definitively established and other ciliary targeting sequences have also been identified (reviewed in Deretic, 2013; Bhogaraju et al, 2013).
Geng, L, Okuhara, D, Yu, Z, Tian, X, Cai, Y, Shibazaki, S, Somlo, S
Mazelova, J, Astuto-Gribble, L, Inoue, H, Tam, BM, Schonteich, E, Prekeris, R, Moritz, OL, Randazzo, PA, Deretic, D
Bhogaraju, S, Engel, BD, Lorentzen, E
Jenkins, PM, Hurd, TW, Zhang, L, McEwen, DP, Brown, RL, Margolis, B, Verhey, KJ, Martens, JR
Deretic, D
Ward, HH, Brown-Glaberman, U, Wang, J, Morita, Y, Alper, SL, Bedrick, EJ, Gattone, VH, Deretic, D, Wandinger-Ness, A
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