HOXD4 gene is transcribed

Stable Identifier
R-HSA-5617874
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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HOXD4 gene is transcribed
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The HOXD4 gene is transcribed to yield mRNA (Moroni et al. 1993, Morrison et al. 1996, Morrison et al. 1997). In mouse embryos Hoxd4 mRNA is observed in rhombomere 7 and caudally in spinal cord and prevertebrae. The HOXD4 promoter region is a target of the microRNA miR-10a, which causes repression of transcription (Tan et al. 2009).
Literature References
PubMed ID Title Journal Year
9272954 HOXD4 and regulation of the group 4 paralog genes

Morrison, A, Ariza-McNaughton, L, Gould, A, Featherstone, M, Krumlauf, R

Development 1997
7908827 Regulation of the human HOXD4 gene by retinoids

Moroni, MC, Viganó, MA, Mavilio, F

Mech. Dev. 1993
8674428 In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer

Morrison, A, Moroni, MC, Ariza-McNaughton, L, Krumlauf, R, Mavilio, F

Development 1996
19232136 Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells

Tan, Y, Zhang, B, Wu, T, Skogerbø, G, Zhu, X, Guo, X, He, S, Chen, R

BMC Mol. Biol. 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
MLL3,4 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
RXRA:RARA,B:atRA [nucleoplasm]
CREBBP [nucleoplasm]
EP300 [nucleoplasm]
NCOA3 [nucleoplasm]
PAX6 [nucleoplasm]
YY1 [nucleoplasm]
Inferred From
Hoxd4 gene is transcribed (Mus musculus)
Authored
May, B  (2014-08-08)
Rezsohazy, R  (2015-11-15)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-15)
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