Expression of Cebpa

Stable Identifier
R-MMU-442497
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Cebpa
In mouse 3T3-L1 pre-adipocytes, Cebpa is expressed during adipocyte differentiation (Cao et al. 1991, Yeh et al. 1995). Ebf1 directly binds one site in the Cebpa promoter and activates transcription of the Cebpa gene (Jimenez et al. 2007).
Literature References
PubMed ID Title Journal Year
17011499 Transcriptional control of adipocyte formation

Farmer, SR

Cell Metab 2006
1840554 Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells

Cao, Z, Umek, RM, McKnight, SL

Genes Dev 1991
7531665 Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins

Yeh, WC, Cao, Z, Classon, M, McKnight, SL

Genes Dev 1995
17060461 Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade

Jimenez, MA, Akerblad, P, Sigvardsson, M, Rosen, ED

Mol Cell Biol 2007
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Wnt-1 or Wnt-10b [extracellular region] (Mus musculus)
Regulator
Tgfb1 [extracellular region] (Mus musculus)
Regulator
Tnf [extracellular region] (Mus musculus)
Positively by
Regulator
Ebf1 [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of CEBPA (Homo sapiens)
Authored
May, B  (2009-05-15)
Reviewed
Sethi, JK  (2011-02-10)
Created
May, B  (2009-09-27)
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