Reactome | B-WICH complex positively regulates rRNA expression

B-WICH complex positively regulates rRNA expression

Stable Identifier

R-HSA-5250924

DOI

10.3180/r-hsa-5250924.1

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

B-WICH complex positively regulates rRNA expression

Click the image above or here to open this pathway in the Pathway Browser

The B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c), SF3B1, DEK, MYBBP1A, and DDX21 (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001, Sarshad et al. 2013, Shen et al. 2013, reviewed in Percipalle and Farrants 2006). B-WICH is found at active rRNA genes as well as at 5S rRNA and 7SL RNA genes. B-WICH appears to remodel chromatin and recruit histone acetyltransferases that modify histones to transcriptionally active states.

Literature References

PubMed ID	Title	Journal	Year
16603771	The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription Farrants, AK, Cavellán, E, Percipalle, P, Asp, P	J. Biol. Chem.	2006
16514417	The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription Farrants, AK, Scheer, U, Cavellán, E, Percipalle, P, Voit, R, Fomproix, N, Thyberg, J, Reimer, G, Krüger, T, Grummt, I	EMBO Rep.	2006
21559432	The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes Böhm, S, Ostlund Farrants, AK, Sadeghifar, F, Mansén, A, Vintermist, A, Percipalle, P, Louvet, E	PLoS ONE	2011
16574391	Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1 Farrants, AK, Percipalle, P	Curr. Opin. Cell Biol.	2006
23667505	The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation Lyu, G, Zhou, T, Zhu, Q, Shen, M, Zhang, F, Gao, Q, Ling, T, Zong, L, Xie, W, Tao, W	PLoS ONE	2013
23555303	Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression Böhm, S, Sarshad, A, Percipalle, P, Fomproix, N, Sadeghifar, F, Vintermist, A, Louvet, E, Al-Muzzaini, B, Östlund, AK, Mori, R	PLoS Genet.	2013