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mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
Stable Identifier
R-ALL-450605
Type
OtherEntity
Compartment
nucleoplasm
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism of RNA (Bos taurus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
HuR (ELAVL1) binds and stabilizes mRNA (Bos taurus)
HuR binds the CRM1 nuclear export machinery (Bos taurus)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Bos taurus)
HuR:mRNA complexes [nucleoplasm] (Bos taurus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Bos taurus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complexes [nucleoplasm] (Bos taurus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Bos taurus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complex translocates from the nucleus to the cytosol (Bos taurus)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Bos taurus)
HuR:mRNA complexes [nucleoplasm] (Bos taurus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Bos taurus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
p-S158,221-HuR binds mRNA (Bos taurus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Bos taurus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
Metabolism of RNA (Canis familiaris)
Regulation of mRNA stability by proteins that bind AU-rich elements (Canis familiaris)
HuR (ELAVL1) binds and stabilizes mRNA (Canis familiaris)
HuR binds the CRM1 nuclear export machinery (Canis familiaris)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Canis familiaris)
HuR:mRNA complexes [nucleoplasm] (Canis familiaris)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Canis familiaris)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complexes [nucleoplasm] (Canis familiaris)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Canis familiaris)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complex translocates from the nucleus to the cytosol (Canis familiaris)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Canis familiaris)
HuR:mRNA complexes [nucleoplasm] (Canis familiaris)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Canis familiaris)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
p-S158,221-HuR binds mRNA (Canis familiaris)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Canis familiaris)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
Metabolism of RNA (Drosophila melanogaster)
Regulation of mRNA stability by proteins that bind AU-rich elements (Drosophila melanogaster)
HuR (ELAVL1) binds and stabilizes mRNA (Drosophila melanogaster)
HuR binds the CRM1 nuclear export machinery (Drosophila melanogaster)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Drosophila melanogaster)
HuR:mRNA complexes [nucleoplasm] (Drosophila melanogaster)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Drosophila melanogaster)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complexes [nucleoplasm] (Drosophila melanogaster)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Drosophila melanogaster)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complex translocates from the nucleus to the cytosol (Drosophila melanogaster)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Drosophila melanogaster)
HuR:mRNA complexes [nucleoplasm] (Drosophila melanogaster)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Drosophila melanogaster)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
p-S158,221-HuR binds mRNA (Drosophila melanogaster)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Drosophila melanogaster)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
Metabolism of RNA (Gallus gallus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Gallus gallus)
HuR (ELAVL1) binds and stabilizes mRNA (Gallus gallus)
p-S158,221-HuR binds mRNA (Gallus gallus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Gallus gallus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
HuR (ELAVL1) binds and stabilizes mRNA (Homo sapiens)
HuR binds the CRM1 nuclear export machinery (Homo sapiens)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Homo sapiens)
HuR:mRNA complexes [nucleoplasm] (Homo sapiens)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Homo sapiens)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complexes [nucleoplasm] (Homo sapiens)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Homo sapiens)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complex translocates from the nucleus to the cytosol (Homo sapiens)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Homo sapiens)
HuR:mRNA complexes [nucleoplasm] (Homo sapiens)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Homo sapiens)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
p-S158,221-HuR binds mRNA (Homo sapiens)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Homo sapiens)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
Metabolism of RNA (Mus musculus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Mus musculus)
HuR (ELAVL1) binds and stabilizes mRNA (Mus musculus)
HuR binds the CRM1 nuclear export machinery (Mus musculus)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Mus musculus)
HuR:mRNA complexes [nucleoplasm] (Mus musculus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Mus musculus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complexes [nucleoplasm] (Mus musculus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Mus musculus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complex translocates from the nucleus to the cytosol (Mus musculus)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Mus musculus)
HuR:mRNA complexes [nucleoplasm] (Mus musculus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Mus musculus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
p-S158,221-HuR binds mRNA (Mus musculus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Mus musculus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
Metabolism of RNA (Rattus norvegicus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Rattus norvegicus)
HuR (ELAVL1) binds and stabilizes mRNA (Rattus norvegicus)
HuR binds the CRM1 nuclear export machinery (Rattus norvegicus)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Rattus norvegicus)
HuR:mRNA complexes [nucleoplasm] (Rattus norvegicus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Rattus norvegicus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complexes [nucleoplasm] (Rattus norvegicus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Rattus norvegicus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complex translocates from the nucleus to the cytosol (Rattus norvegicus)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Rattus norvegicus)
HuR:mRNA complexes [nucleoplasm] (Rattus norvegicus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Rattus norvegicus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
p-S158,221-HuR binds mRNA (Rattus norvegicus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Rattus norvegicus)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
Metabolism of RNA (Sus scrofa)
Regulation of mRNA stability by proteins that bind AU-rich elements (Sus scrofa)
HuR (ELAVL1) binds and stabilizes mRNA (Sus scrofa)
HuR binds the CRM1 nuclear export machinery (Sus scrofa)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Sus scrofa)
HuR:mRNA complexes [nucleoplasm] (Sus scrofa)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Sus scrofa)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complexes [nucleoplasm] (Sus scrofa)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Sus scrofa)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR:mRNA complex translocates from the nucleus to the cytosol (Sus scrofa)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Sus scrofa)
HuR:mRNA complexes [nucleoplasm] (Sus scrofa)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Sus scrofa)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
p-S158,221-HuR binds mRNA (Sus scrofa)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Sus scrofa)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
Metabolism of RNA (Xenopus tropicalis)
Regulation of mRNA stability by proteins that bind AU-rich elements (Xenopus tropicalis)
HuR (ELAVL1) binds and stabilizes mRNA (Xenopus tropicalis)
p-S158,221-HuR binds mRNA (Xenopus tropicalis)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Xenopus tropicalis)
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
General
Phosphorylated HuR (phosphoserine158 and phosphoserine318) binds AU-rich elements in the Cyclooxygenase-2 (COX-2, PTGS2) mRNA.
Literature References
PubMed ID
Title
Journal
Year
17392515
Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2
Pfeilschifter, J
,
Müller, R
,
Doller, A
,
Huwiler, A
,
Eberhardt, W
,
Radeke, HH
Mol Biol Cell
2007
Participates
as an input of
p-S158,221-HuR binds mRNA (Drosophila melanogaster)
p-S158,221-HuR binds mRNA (Gallus gallus)
p-S158,221-HuR binds mRNA (Xenopus tropicalis)
p-S158,221-HuR binds mRNA (Sus scrofa)
p-S158,221-HuR binds mRNA (Bos taurus)
p-S158,221-HuR binds mRNA (Canis familiaris)
p-S158,221-HuR binds mRNA (Rattus norvegicus)
p-S158,221-HuR binds mRNA (Mus musculus)
p-S158,221-HuR binds mRNA (Homo sapiens)
as a component of
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Bos taurus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Drosophila melanogaster)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Gallus gallus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Xenopus tropicalis)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Sus scrofa)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Rattus norvegicus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Mus musculus)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Canis familiaris)
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Homo sapiens)
Cross References
ChEBI
33697
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