Reactome | polySUMO2,3-CDCA8 [cytosol]

polySUMO2,3-CDCA8 [cytosol]

Stable Identifier

R-HSA-4655328

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Borealin

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
18946085	RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin Nigg, EA, Haindl, M, Klein, UR, Muller, S	Mol. Biol. Cell	2009

External Reference Information

External Reference

UniProt:Q53HL2 CDCA8

Gene Names

CDCA8, PESCRG3

Chain

chain:1-280

Reference Genes

BioGPS Gene:55143 CDCA8

COSMIC (genes):CDCA8 CDCA8

CTD Gene:55143 CDCA8

dbSNP Gene:55143 CDCA8

ENSEMBL:ENSG00000134690 CDCA8

ENSEMBL_homo_sapiens_GENE:ENSG00000134690.11 CDCA8

HGNC:14629 CDCA8

KEGG Gene (Homo sapiens):55143 CDCA8

Monarch:55143 CDCA8

NCBI Gene:55143 CDCA8

OMIM:609977 CDCA8

UCSC:Q53HL2 CDCA8

Reference Transcript

Other Identifiers

11741015_a_at

11744598_a_at

16662648

221520_PM_s_at

221520_s_at

2330774

2330775

2330776

2330777

2330778

2330780

2330782

2330785

2330786

2330787

2330788

2330792

2330793

2330794

2330799

52966_at

55143

7900167

A_14_P107538

A_23_P375

GE55755

GO:0000070

GO:0000278

GO:0000281

GO:0000775

GO:0000910

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0007010

GO:0007049

GO:0007059

GO:0007080

GO:0010369

GO:0015630

GO:0023052

GO:0030496

GO:0032133

GO:0032991

GO:0043226

GO:0045171

GO:0051233

GO:0051256

GO:0051276

GO:0051301

GO:0090267

GO:0090307

GO:0140014

GO:1901970

GO:1902425

GO:1903490

HMNXSV003014760

ILMN_1709294

PH_hs_0031222

TC01000476.hg

g12804484_3p_a_at

Participates

as a component of

SUMO2,3:Chromosome passenger complex [cytosol] (Homo sapiens)

Other forms of this molecule

CDCA8 [nucleoplasm]

CDCA8 [cytosol]

Inferred To

Homologues of polySUMO2,3-CDCA8 [cytosol] (Drosophila melanogaster)

borr [cytosol] (Drosophila melanogaster)

cdca8 [cytosol] (Xenopus tropicalis)

aust [cytosol] (Drosophila melanogaster)

Cdca8 [cytosol] (Mus musculus)

Cdca8 [cytosol] (Rattus norvegicus)

polySUMO2,3-CDCA8 [cytosol] (Gallus gallus)

CDCA8 [cytosol] (Bos taurus)

CDCA8 [cytosol] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at unknown position

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001243804.1, NP_060571.1

OpenTargets

ENSG00000134690

HPA

ENSG00000134690-CDCA8

GeneCards

Q53HL2

Ensembl

ENST00000373055, ENSP00000316121, ENSP00000362146, ENST00000327331, ENSG00000134690

PRO

Q53HL2

Pharos - Targets

Q53HL2

PDB

6YIE, 2KDD, 2RAW, 6YIH, 7U5V, 2QFA, 2RAX, 6YIF

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.964	21
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.868	10
UniProt:P21579 SYT1	7	SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508)	0.527	2