Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDCA8 [cytosol]
Stable Identifier
R-HSA-375288
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Borealin
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
CDCA8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q53HL2 CDCA8
Gene Names
CDCA8, PESCRG3
Chain
chain:1-280
Reference Genes
BioGPS Gene:55143 CDCA8
COSMIC (genes):CDCA8 CDCA8
CTD Gene:55143 CDCA8
dbSNP Gene:55143 CDCA8
ENSEMBL:ENSG00000134690 CDCA8
ENSEMBL_homo_sapiens_GENE:ENSG00000134690.11 CDCA8
HGNC:14629 CDCA8
KEGG Gene (Homo sapiens):55143 CDCA8
Monarch:55143 CDCA8
NCBI Gene:55143 CDCA8
OMIM:609977 CDCA8
UCSC:Q53HL2 CDCA8
Reference Transcript
RefSeq:NM_018101.3 CDCA8
RefSeq:NM_001256875.1 CDCA8
Other Identifiers
11741015_a_at
11744598_a_at
16662648
221520_PM_s_at
221520_s_at
2330774
2330775
2330776
2330777
2330778
2330780
2330782
2330785
2330786
2330787
2330788
2330792
2330793
2330794
2330799
52966_at
55143
7900167
A_14_P107538
A_23_P375
GE55755
GO:0000070
GO:0000278
GO:0000281
GO:0000775
GO:0000910
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0007010
GO:0007049
GO:0007059
GO:0007080
GO:0010369
GO:0015630
GO:0023052
GO:0030496
GO:0032133
GO:0032991
GO:0043226
GO:0045171
GO:0051233
GO:0051256
GO:0051276
GO:0051301
GO:0090267
GO:0090307
GO:0140014
GO:1901970
GO:1902425
GO:1903490
HMNXSV003014760
ILMN_1709294
PH_hs_0031222
TC01000476.hg
g12804484_3p_a_at
Participates
as a component of
Chromosome passenger complex [cytosol] (Homo sapiens)
Other forms of this molecule
polySUMO2,3-CDCA8 [cytosol]
CDCA8 [nucleoplasm]
Inferred To
cdca8 [cytosol]
(Xenopus tropicalis)
Cdca8 [cytosol]
(Mus musculus)
Cdca8 [cytosol]
(Rattus norvegicus)
CDCA8 [cytosol]
(Bos taurus)
CDCA8 [cytosol]
(Canis familiaris)
CDCA8 [cytosol]
(Gallus gallus)
CDCA8 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001243804.1
,
NP_060571.1
OpenTargets
ENSG00000134690
HPA
ENSG00000134690-CDCA8
GeneCards
Q53HL2
Ensembl
ENST00000373055
,
ENSP00000316121
,
ENSP00000362146
,
ENST00000327331
,
ENSG00000134690
PRO
Q53HL2
Pharos - Targets
Q53HL2
PDB
6YIE
,
2KDD
,
2RAW
,
6YIH
,
7U5V
,
2QFA
,
2RAX
,
6YIF
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.964
21
UniProt:Q96GD4 AURKB
3
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [nucleoplasm]
(R-HSA-4655360)
AURKB [cytosol]
(R-HSA-174231)
0.868
10
UniProt:P21579 SYT1
7
SYT1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869113)
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
(R-HSA-210536)
SYT1 [synaptic vesicle membrane]
(R-HSA-194789)
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-372514)
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917741)
SYT1 [plasma membrane]
(R-HSA-168786)
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-372508)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text