Reactome | SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Stable Identifier

R-HSA-917741

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

Synonyms

Synaptotagmin-1, SYT1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P21579 SYT1

Gene Names

SYT1, SVP65, SYT

Chain

chain:1-422

Reference Genes

BioGPS Gene:6857 SYT1

COSMIC (genes):SYT1 SYT1

CTD Gene:6857 SYT1

dbSNP Gene:6857 SYT1

ENSEMBL:ENSG00000067715 SYT1

HGNC:11509 SYT1

KEGG Gene (Homo sapiens):6857 SYT1

Monarch:6857 SYT1

NCBI Gene:6857 SYT1

OMIM:185605 SYT1

UCSC:P21579 SYT1

Reference Transcript

Other Identifiers

0001580128

0102810193

11724585_a_at

11724586_a_at

11724587_a_at

16754536

203998_PM_s_at

203998_s_at

203999_PM_at

203999_at

3254781

3423629

3423630

3423631

3423632

3423633

3423634

3423635

3423663

3423676

3423705

3423721

3423722

3423723

3423724

3423725

3423736

3423751

3423753

3423754

40075_at

6857

7957338

A_14_P100506

A_23_P36795

A_33_P3237201

GE57966

GO:0000149

GO:0000902

GO:0001786

GO:0003674

GO:0005509

GO:0005513

GO:0005515

GO:0005516

GO:0005543

GO:0005544

GO:0005546

GO:0005575

GO:0005622

GO:0005737

GO:0005794

GO:0005886

GO:0006810

GO:0007267

GO:0007268

GO:0007269

GO:0007420

GO:0008021

GO:0008022

GO:0008150

GO:0008289

GO:0014059

GO:0016020

GO:0016021

GO:0016079

GO:0016192

GO:0017075

GO:0017156

GO:0017157

GO:0017158

GO:0019905

GO:0022607

GO:0030054

GO:0030141

GO:0030154

GO:0030276

GO:0030285

GO:0030348

GO:0030424

GO:0030658

GO:0030669

GO:0030672

GO:0031045

GO:0031340

GO:0031410

GO:0033603

GO:0040007

GO:0042584

GO:0042734

GO:0042802

GO:0043005

GO:0043167

GO:0043226

GO:0043229

GO:0044306

GO:0045202

GO:0045956

GO:0046872

GO:0046982

GO:0048278

GO:0048306

GO:0048488

GO:0048791

GO:0048856

GO:0050750

GO:0050806

GO:0051291

GO:0051592

GO:0051966

GO:0060076

GO:0060201

GO:0060203

GO:0061024

GO:0061202

GO:0061669

GO:0061891

GO:0065003

GO:0070083

GO:0070382

GO:0071277

GO:0071911

GO:0098686

GO:0098746

GO:0098978

GO:0099502

GO:1903235

GO:1903305

GO:1903861

GO:2000300

HMNXSV003056582

Hs.154679.0.S1_3p_a_at

Hs.154679.0.S3_3p_at

ILMN_1742881

ILMN_1838187

ILMN_3191918

M55047_at

PH_hs_0009313

TC12000660.hg

Participates

as a component of

GABA Loaded synaptic vesicle [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)

Other forms of this molecule

SYT1 [clathrin-coated endocytic vesicle membrane]

SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]

SYT1 [clathrin-sculpted glutamate transport vesicle membrane]

SYT1 [synaptic vesicle membrane]

SYT1 [plasma membrane]

SYT1 [clathrin-sculpted monoamine transport vesicle membrane]

Inferred To

Homologues of SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)

SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Bos taurus)

SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)

SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Canis familiaris)

SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Gallus gallus)

SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Sus scrofa)

syt1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Xenopus tropicalis)

snt-1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)

syt1a [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Danio rerio)

snt-2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)

Syt1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Drosophila melanogaster)

Syt1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Mus musculus)

Syt1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Rattus norvegicus)

snt-3 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011537012.1, NP_001129278.1, XP_016875398.1, NP_001129277.1, NP_005630.1

OpenTargets

ENSG00000067715

GeneCards

P21579

HPA

ENSG00000067715-SYT1

Ensembl

ENST00000393240, ENST00000552744, ENSP00000447575, ENSP00000261205, ENST00000261205, ENSP00000376932, ENSG00000067715

PRO

P21579

Pharos - Targets

P21579

Orphanet

24960

HMDB Protein

HMDBP08028

PDB

2R83, 3F04, 3F00, 6G5F, 2K8M, 2LHA, 6U4W, 6U4U, 3F05, 2KI6, 3F01, 4V11, 6ZVN, 6G5K, 2K4A, 2N1T, 6TZ3, 6U41, 2K45, 4ISQ, 6QNS

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG	12	monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.581	3
UniProt:Q9P0S9 TM14C			0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:Q8N6G5 CSGALNACT2	1	CSGALNACT2 [Golgi membrane] (R-HSA-1971506)	0.556	3
UniProt:P30301 MIP	1	MIP [plasma membrane] (R-HSA-432026)	0.556	3
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.556	3
UniProt:Q8TBM7 TM254			0.556	3
UniProt:O95159 ZFPL1			0.556	3
UniProt:O43169 CYB5B	1	CYB5B [mitochondrial outer membrane] (R-HSA-8943390)	0.556	3
UniProt:Q96F15 GIMA5			0.556	3
UniProt:P30519 HMOX2	3	HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.556	3
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.556	3
UniProt:O00305-2 CACNB4			0.527	2
UniProt:P16473 TSHR	1	TSHR [plasma membrane] (R-HSA-391371)	0.508	2

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