Reactome | BRMS1 [nucleoplasm]

BRMS1 [nucleoplasm]

Stable Identifier

R-HSA-4650034

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Breast cancer metastasis-suppressor 1, BRMS1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        BRMS1 [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        BRMS1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HCU9 BRMS1

Gene Names

BRMS1

Chain

chain:1-246

Reference Genes

BioGPS Gene:25855 BRMS1

COSMIC (genes):BRMS1 BRMS1

CTD Gene:25855 BRMS1

dbSNP Gene:25855 BRMS1

ENSEMBL:ENSG00000174744 BRMS1

ENSEMBL_homo_sapiens_GENE:ENSG00000174744.14 BRMS1

HGNC:17262 BRMS1

KEGG Gene (Homo sapiens):25855 BRMS1

Monarch:25855 BRMS1

NCBI Gene:25855 BRMS1

OMIM:606259 BRMS1

UCSC:Q9HCU9 BRMS1

Reference Transcript

RefSeq:NM_015399.3 BRMS1

Other Identifiers

11732098_x_at

11744290_a_at

11744291_x_at

11754127_a_at

11754128_x_at

16740752

215631_PM_s_at

215631_s_at

25855

3378211

3378212

3378214

3378216

3378217

3378218

3378220

3378222

3378223

3378224

3378227

37101_at

37102_at

7949603

A_23_P75500

A_33_P3367017

GE56225

GO:0000122

GO:0000228

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006915

GO:0012501

GO:0016580

GO:0023052

GO:0030336

GO:0030512

GO:0032088

GO:0036211

GO:0042826

GO:0042981

GO:0043226

GO:0045892

GO:0048870

GO:0051059

GO:0070822

GO:0090312

GO:1902455

GO:1902459

GO:2000210

HMNXSV003011442

Hs.306186.0.S1_3p_s_at

ILMN_1719165

ILMN_2398432

TC11001964.hg

Participates

as a component of

Sin3A complex [nucleoplasm] (Homo sapiens)

Inferred To

BRMS1 [nucleoplasm] (Bos taurus)

BRMS1 [nucleoplasm] (Canis familiaris)

BRMS1 [nucleoplasm] (Dictyostelium discoideum)

BRMS1 [nucleoplasm] (Sus scrofa)

brms1 [nucleoplasm] (Xenopus tropicalis)

dep1 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of BRMS1 [nucleoplasm] (Gallus gallus)

DEP1 [nucleoplasm] (Saccharomyces cerevisiae)

Brms1 [nucleoplasm] (Drosophila melanogaster)

Brms1 [nucleoplasm] (Mus musculus)

Brms1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_056214.1

OpenTargets

ENSG00000174744

GeneCards

Q9HCU9

HPA

ENSG00000174744-BRMS1

Ensembl

ENSG00000174744, ENST00000359957, ENSP00000353042

PRO

Q9HCU9

Pharos - Targets

Q9HCU9

PDB

2XUS, 4AUV

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13287 NMI	1	NMI [cytosol] (R-HSA-9731022)	0.786	7
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.784	5
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.723	4
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	2
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.524	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.524	2