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DKK1 [extracellular region]
Stable Identifier
R-HSA-452535
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Dickkopf-related protein 1, DKK1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by LRP5 mutants (Homo sapiens)
misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK1 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists (Homo sapiens)
DKK and KRM bind LRP5/6 (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK1 [extracellular region] (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK1 [extracellular region] (Homo sapiens)
DKK promotes clathrin-dependent internalization of LRP6 (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK1 [extracellular region] (Homo sapiens)
WNT binds to FZD and LRP5/6 (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
DKK [extracellular region] (Homo sapiens)
DKK1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94907 DKK1
Gene Names
DKK1, UNQ492/PRO1008
Chain
signal peptide:1-31, chain:32-266
Reference Genes
BioGPS Gene:22943 DKK1
COSMIC (genes):DKK1 DKK1
CTD Gene:22943 DKK1
dbSNP Gene:22943 DKK1
ENSEMBL:ENSG00000107984.10 DKK1
HGNC:2891 DKK1
KEGG Gene (Homo sapiens):22943 DKK1
Monarch:22943 DKK1
NCBI Gene:22943 DKK1
OMIM:605189 DKK1
UCSC:O94907 DKK1
Reference Transcript
RefSeq:NM_012242.2 DKK1
Other Identifiers
0000510427
11718141_at
16705011
204602_PM_at
204602_at
22943
3247173
3247174
3247176
3247179
3247182
3247183
3247184
3247185
3247186
35977_at
7927631
A_14_P101033
A_23_P24129
GE58475
GO:0000122
GO:0000904
GO:0001706
GO:0001707
GO:0001942
GO:0002090
GO:0005515
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005768
GO:0005886
GO:0006351
GO:0006355
GO:0007275
GO:0007492
GO:0007611
GO:0008083
GO:0010628
GO:0010942
GO:0010977
GO:0012501
GO:0016055
GO:0016192
GO:0023052
GO:0030111
GO:0030154
GO:0030178
GO:0030279
GO:0030326
GO:0030514
GO:0030900
GO:0031410
GO:0031901
GO:0032091
GO:0032526
GO:0033137
GO:0034330
GO:0036211
GO:0039706
GO:0042662
GO:0042663
GO:0043066
GO:0043226
GO:0043507
GO:0045813
GO:0048019
GO:0048856
GO:0050750
GO:0050807
GO:0050877
GO:0051966
GO:0060070
GO:0060173
GO:0060323
GO:0060325
GO:0060394
GO:0061743
GO:0065003
GO:0090082
GO:0090090
GO:0090244
GO:0098772
GO:0098883
GO:1901216
GO:1901296
GO:1902949
GO:1904338
GO:1904723
GO:1904958
GO:1905607
GO:2000096
GO:2000272
GO:2000726
HMNXSV003031538
ILMN_1773337
ILMN_2174189
PH_hs_0003037
TC10000350.hg
g7110718_3p_at
Participates
as a member of
DKK [extracellular region] (Homo sapiens)
Other forms of this molecule
DKK1 [early endosome membrane]
Inferred To
Homologues of DKK1 [extracellular region]
(Dictyostelium discoideum)
DKK1 [extracellular region]
(Canis familiaris)
DKK1 [extracellular region]
(Danio rerio)
DKK1 [extracellular region]
(Dictyostelium discoideum)
DKK1 [extracellular region]
(Sus scrofa)
dkk1 [extracellular region]
(Xenopus tropicalis)
DKK4 [extracellular region]
(Gallus gallus)
Dkk1 [extracellular region]
(Mus musculus)
Dkk1 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_036374.1
OpenTargets
ENSG00000107984
ZINC - Substances
DKK1_HUMAN
HPA
ENSG00000107984-DKK1
GeneCards
O94907
Ensembl
ENST00000373970
,
ENSP00000363081
,
ENSG00000107984
ZINC target
O94907
PRO
O94907
Pharos - Targets
O94907
Orphanet
21409
ZINC - Predictions - Purchasable
DKK1_HUMAN
PDB
5FWW
,
3S2K
,
3S8V
,
3SOQ
,
5GJE
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75581 LRP6
8
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6N [extracellular region]
(R-HSA-5334021)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
LRP6 [plasma membrane]
(R-HSA-206252)
0.879
15
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