Reactome | DKK1 [extracellular region]

DKK1 [extracellular region]

Stable Identifier

R-HSA-452535

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Dickkopf-related protein 1, DKK1_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O94907 DKK1

Gene Names

DKK1, UNQ492/PRO1008

Chain

signal peptide:1-31, chain:32-266

Reference Genes

BioGPS Gene:22943 DKK1

COSMIC (genes):DKK1 DKK1

CTD Gene:22943 DKK1

dbSNP Gene:22943 DKK1

ENSEMBL:ENSG00000107984 DKK1

HGNC:2891 DKK1

KEGG:hsa:22943 DKK1

Monarch:22943 DKK1

NCBI Gene:22943 DKK1

OMIM:605189 DKK1

UCSC:O94907 DKK1

Reference Transcript

RefSeq:NM_012242.2 DKK1

Other Identifiers

11718141_at

16705011

204602_PM_at

204602_at

22943

3247173

3247174

3247175

3247176

3247177

3247179

3247180

3247181

3247182

3247183

3247184

3247185

3247186

3247187

3247188

35977_at

7927631

A_14_P101033

A_23_P24129

GE58475

GO:0000122

GO:0000902

GO:0001706

GO:0001707

GO:0001942

GO:0002090

GO:0003129

GO:0003170

GO:0003197

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006355

GO:0007275

GO:0007492

GO:0007611

GO:0008083

GO:0010628

GO:0010977

GO:0016055

GO:0030111

GO:0030178

GO:0030279

GO:0030326

GO:0030514

GO:0030900

GO:0031901

GO:0032091

GO:0032526

GO:0033137

GO:0034330

GO:0039706

GO:0042662

GO:0042663

GO:0043066

GO:0043523

GO:0045813

GO:0046330

GO:0048018

GO:0048019

GO:0048856

GO:0050750

GO:0050807

GO:0050877

GO:0051966

GO:0060070

GO:0060173

GO:0060323

GO:0060325

GO:0060392

GO:0061743

GO:0090090

GO:0090244

GO:0098772

GO:0098883

GO:1904338

GO:1904723

GO:1904958

GO:1905607

GO:2000096

GO:2000726

HMNXSV003031538

ILMN_1773337

ILMN_2174189

PH_hs_0003037

TC10000350.hg

g7110718_3p_at

Participates

as a member of

DKK [extracellular region] (Homo sapiens)

Other forms of this molecule

DKK1 [early endosome membrane]

Inferred To

Homologues of DKK1 [extracellular region] (Dictyostelium discoideum)

DKK1 [extracellular region] (Bos taurus)

DKK1 [extracellular region] (Canis familiaris)

DKK1 [extracellular region] (Dictyostelium discoideum)

DKK1 [extracellular region] (Gallus gallus)

DKK1 [extracellular region] (Sus scrofa)

dkk1 [extracellular region] (Xenopus tropicalis)

Dkk1 [extracellular region] (Mus musculus)

dkk1b [extracellular region] (Danio rerio)

Cross References

ENSEMBL

ENST00000373970, ENSG00000107984, ENSP00000363081

OpenTargets

ENSG00000107984

GeneCards

DKK1

HPA

ENSG00000107984-DKK1

ZINC - Substances

DKK1_HUMAN

ZINC target

O94907

PRO

O94907

Pharos - Targets

O94907

GlyGen

O94907

Orphanet

DKK1

ZINC - Predictions - Purchasable

DKK1_HUMAN

PDB

3S8V, 5GJE, 3S2K, 3SOQ, 5FWW

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75581 LRP6	8	LRP6 [plasma membrane] (R-HSA-206252) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) LRP6N [extracellular region] (R-HSA-5334021) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6 [early endosome membrane] (R-HSA-5368481) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884)	0.94	18
UniProt:O75197 LRP5	5	LRP5 [plasma membrane] (R-HSA-201671) p-5S,5T-LRP5 [plasma membrane] (R-HSA-1458893) p-3S,2T-LRP5 [plasma membrane] (R-HSA-1458905) LRP5 [early endosome membrane] (R-HSA-5368479) LRP5 D666_L809del [plasma membrane] (R-HSA-5339694)	0.527	3

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