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Activation of Ca-permeable Kainate Receptor
Stable Identifier
R-HSA-451308
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of kainate receptors upon glutamate binding (Homo sapiens)
Ionotropic activity of kainate receptors (Homo sapiens)
Activation of Ca-permeable Kainate Receptor (Homo sapiens)
General
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|
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Level 2
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SBGN
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Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.
Literature References
PubMed ID
Title
Journal
Year
10718099
Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders
Lees, GJ
Drugs
2000
Participants
Events
kainate receptor binds glutamate
(Homo sapiens)
Activation of Ca-permeable Kainate receptors
(Homo sapiens)
Participates
as an event of
Ionotropic activity of kainate receptors (Homo sapiens)
Event Information
Go Biological Process
chemical synaptic transmission (0007268)
Orthologous Events
Activation of Ca-permeable Kainate Receptor (Bos taurus)
Activation of Ca-permeable Kainate Receptor (Caenorhabditis elegans)
Activation of Ca-permeable Kainate Receptor (Canis familiaris)
Activation of Ca-permeable Kainate Receptor (Drosophila melanogaster)
Activation of Ca-permeable Kainate Receptor (Gallus gallus)
Activation of Ca-permeable Kainate Receptor (Mus musculus)
Activation of Ca-permeable Kainate Receptor (Rattus norvegicus)
Activation of Ca-permeable Kainate Receptor (Sus scrofa)
Cross References
BioModels Database
BIOMD0000000569
,
BIOMD0000000467
,
BIOMD0000000468
,
BIOMD0000000088
Authored
Mahajan, SS (2010-01-15)
Reviewed
Tukey, D (2009-11-18)
Created
Mahajan, SS (2010-01-05)
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