Reactome | kainate receptor binds glutamate

kainate receptor binds glutamate

Stable Identifier

R-HSA-451283

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of kainate receptors upon glutamate binding (Homo sapiens)
      - Ionotropic activity of kainate receptors (Homo sapiens)
        
        Activation of Ca-permeable Kainate Receptor (Homo sapiens)
        
        kainate receptor binds glutamate (Homo sapiens)

General

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Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.

Literature References

PubMed ID	Title	Journal	Year
19342380	Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis Gill, MB, Swanson, GT, Vivithanaporn, P	J Biol Chem	2009