NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]

Stable Identifier
R-HSA-450971
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NNT (nicotinamide nucleotide transhydrogenase) associated with the inner mitochondrial membrane catalyzes the reaction of mitochondrial NADPH and NAD+ to form NADP+ and NADH. The reaction is coupled to the translocation of a proton across the inner mitochondrial membrane into the mitochondrial matrix (White et al, 2000). The active form of NNT is inferred to be a homodimer based on the known structure of its bovine homolog (Yamaguchi and Hatefi 1991).

Literature References
PubMed ID Title Journal Year
10673423 The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria

White, SA, Peake, SJ, McSweeney, S, Leonard, G, Cotton, NP, Jackson, JB

Structure 2000
2005110 Mitochondrial energy-linked nicotinamide nucleotide transhydrogenase. Membrane topography of the bovine enzyme

Yamaguchi, M, Hatefi, Y

J Biol Chem 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD(P)+ transhydrogenase activity of NNT dimer [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created