NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]

Stable Identifier
R-HSA-450971
Type
Reaction
Species
Homo sapiens
Compartment
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NNT (nicotinamide nucleotide transhydrogenase) associated with the inner mitochondrial membrane catalyzes the reaction of mitochondrial NADPH and NAD+ to form NADP+ and NADH. The reaction is coupled to the translocation of a proton across the inner mitochondrial membrane into the mitochondrial matrix (White et al, 2000). The active form of NNT is inferred to be a homodimer based on the known structure of its bovine homolog (Yamaguchi and Hatefi 1991).

Literature References
PubMed ID Title Journal Year
2005110 Mitochondrial energy-linked nicotinamide nucleotide transhydrogenase. Membrane topography of the bovine enzyme

Yamaguchi, M, Hatefi, Y

J Biol Chem 1991
10673423 The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria

Peake, SJ, Jackson, JB, Leonard, G, McSweeney, S, White, SA, Cotton, NP

Structure 2000
Participants
Participates
Catalyst Activity

NAD(P)+ transhydrogenase activity of NNT dimer [mitochondrial inner membrane]

Orthologous Events
Cross References
Rhea
Authored
Created
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