NNT (nicotinamide nucleotide transhydrogenase) associated with the inner mitochondrial membrane catalyzes the reaction of mitochondrial NADPH and NAD+ to form NADP+ and NADH. The reaction is coupled to the translocation of a proton across the inner mitochondrial membrane into the mitochondrial matrix (White et al, 2000). The active form of NNT is inferred to be a homodimer based on the known structure of its bovine homolog (Yamaguchi and Hatefi 1991).
Yamaguchi, M, Hatefi, Y
Peake, SJ, Jackson, JB, Leonard, G, McSweeney, S, White, SA, Cotton, NP
NAD(P)+ transhydrogenase activity of NNT dimer [mitochondrial inner membrane]
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