Reactome | NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]

NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]

Stable Identifier

R-HSA-450971

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrion

ReviewStatus

5/5

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NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]

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NNT (nicotinamide nucleotide transhydrogenase) associated with the inner mitochondrial membrane catalyzes the reaction of mitochondrial NADPH and NAD+ to form NADP+ and NADH. The reaction is coupled to the translocation of a proton across the inner mitochondrial membrane into the mitochondrial matrix (White et al, 2000). The active form of NNT is inferred to be a homodimer based on the known structure of its bovine homolog (Yamaguchi and Hatefi 1991).

Literature References

PubMed ID	Title	Journal	Year
2005110	Mitochondrial energy-linked nicotinamide nucleotide transhydrogenase. Membrane topography of the bovine enzyme Yamaguchi, M, Hatefi, Y	J Biol Chem	1991
10673423	The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria Peake, SJ, Jackson, JB, Leonard, G, McSweeney, S, White, SA, Cotton, NP	Structure	2000