IL27:EBI3 [endoplasmic reticulum lumen]

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Interleukin27 complex formation
Interleukin 27 subunit beta(EBI3) is expressed in cells and accumulated in the endoplasmic reticulum and associated with the molecular chaperone calnexin (PMID:9342359)

Computational and biological analyses of the IL-27 binding site 1 to its receptor revealed important structural proximities with the ciliary neurotrophic factor group of cytokines and highlighted the contribution of p28Trp97, as well as of EBI3 Phe97, Asp210, and Glu159, as key residues in the interactions between both cytokine subunits (PMID: 20974977)

Literature References
PubMed ID Title Journal Year
12121660 IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells

Vaisberg, E, Gorman, DM, Timans, JC, Gilbert, J, Mattson, JD, Hibbert, L, Travis, M, Rennick, D, To, W, Kastelein, RA, Kanzler, H, Zurawski, S, Cheung, J, Rosales, R, Pflanz, S, Wagner, JL, Blumenschein, WM, Bazan, JF, de Waal Malefyt, R, Churakova, T, McClanahan, TK

Immunity 2002
9342359 Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Birkenbach, M, Devergne, O, Kieff, E

Proc. Natl. Acad. Sci. U.S.A. 1997
Inferred To
Cite Us!