IL27:EBI3 [endoplasmic reticulum lumen]

Stable Identifier
R-HSA-8950372
Type
Complex
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Interleukin-27
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General

Interleukin27 complex formation
Interleukin 27 subunit beta(EBI3) is expressed in cells and accumulated in the endoplasmic reticulum and associated with the molecular chaperone calnexin (PMID:9342359)

Computational and biological analyses of the IL-27 binding site 1 to its receptor revealed important structural proximities with the ciliary neurotrophic factor group of cytokines and highlighted the contribution of p28Trp97, as well as of EBI3 Phe97, Asp210, and Glu159, as key residues in the interactions between both cytokine subunits (PMID: 20974977)


Literature References
PubMed ID Title Journal Year
12121660 IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells

Vaisberg, E, Gorman, DM, Timans, JC, Gilbert, J, Mattson, JD, Hibbert, L, Travis, M, Rennick, D, To, W, Kastelein, RA, Kanzler, H, Zurawski, S, Cheung, J, Rosales, R, Pflanz, S, Wagner, JL, Blumenschein, WM, Bazan, JF, de Waal Malefyt, R, Churakova, T, McClanahan, TK

Immunity 2002
9342359 Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Birkenbach, M, Devergne, O, Kieff, E

Proc. Natl. Acad. Sci. U.S.A. 1997
Participants
components
Participates
as an output of
as an input of
Inferred To
IL27:EBI3 [endoplasmic reticulum lumen] (Bos taurus)
IL27:EBI3 [endoplasmic reticulum lumen] (Canis familiaris)
IL27:EBI3 [endoplasmic reticulum lumen] (Mus musculus)
IL27:EBI3 [endoplasmic reticulum lumen] (Rattus norvegicus)
IL27:EBI3 [endoplasmic reticulum lumen] (Sus scrofa)
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