IL27:EBI3

Stable Identifier
R-HSA-8950372
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
Interleukin-27
Locations in the PathwayBrowser
Summation

Interleukin27 complex formation
Interleukin 27 subunit beta(EBI3) is expressed in cells and accumulated in the endoplasmic reticulum and associated with the molecular chaperone calnexin (PMID:9342359)

Computational and biological analyses of the IL-27 binding site 1 to its receptor revealed important structural proximities with the ciliary neurotrophic factor group of cytokines and highlighted the contribution of p28Trp97, as well as of EBI3 Phe97, Asp210, and Glu159, as key residues in the interactions between both cytokine subunits (PMID: 20974977)


Literature References
PubMed ID Title Journal Year
9342359 Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Devergne, O, Birkenbach, M, Kieff, E

Proc. Natl. Acad. Sci. U.S.A. 1997
12121660 IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells

Pflanz, S, Timans, JC, Cheung, J, Rosales, R, Kanzler, H, Gilbert, J, Hibbert, L, Churakova, T, Travis, M, Vaisberg, E, Blumenschein, WM, Mattson, JD, Wagner, JL, To, W, Zurawski, S, McClanahan, TK, Gorman, DM, Bazan, JF, de Waal Malefyt, R, Rennick, D, Kastelein, RA

Immunity 2002
Participants
Participant Of
Inferred To