Reactome | THRB [nucleoplasm]

THRB [nucleoplasm]

Stable Identifier

R-HSA-446179

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Thyroid hormone receptor beta, THB_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10828 THRB

Gene Names

THRB, ERBA2, NR1A2, THR1

Chain

chain:1-461

Reference Genes

BioGPS Gene:7068 THRB

COSMIC - genes:THRB THRB

CTD Gene:7068 THRB

dbSNP Gene:7068 THRB

ENSEMBL:ENSG00000151090 THRB

HGNC:11799 THRB

KEGG:hsa:7068 THRB

Monarch:7068 THRB

NCBI Gene:7068 THRB

OMIM:190160 THRB

UCSC:P10828 THRB

Reference Transcript

Participates

as an input of

as a member of

NR [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K50,K146,K443-THRB [nucleoplasm]

polySUMO3-K50,K146,K443-THRB [nucleoplasm]

Inferred To

thrb [nucleoplasm] (Xenopus tropicalis)

THRB [nucleoplasm] (Bos taurus)

THRB [nucleoplasm] (Canis familiaris)

THRB [nucleoplasm] (Danio rerio)

THRB [nucleoplasm] (Gallus gallus)

THRB [nucleoplasm] (Mus musculus)

THRB [nucleoplasm] (Rattus norvegicus)

THRB [nucleoplasm] (Sus scrofa)

nhr-2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of THRB [nucleoplasm] (Caenorhabditis elegans)

Eip75B [nucleoplasm] (Drosophila melanogaster)

nhr-7 [nucleoplasm] (Caenorhabditis elegans)

nhr-85 [nucleoplasm] (Caenorhabditis elegans)

sex-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001341641.1, NP_001361751.1, XP_054203658.1, XP_047304762.1, XP_047304749.1, XP_024309502.1, XP_047304745.1, XP_054203649.1, XP_054203670.1, XP_054203659.1, XP_054203664.1, XP_054203647.1, XP_054203666.1, XP_011532352.1, XP_047304761.1, NP_001361754.1, XP_054203674.1, XP_054203676.1, XP_054203661.1, XP_054203648.1, XP_047304771.1, NP_001341638.1, NP_001341642.1, XP_054203657.1, XP_047304750.1, XP_047304754.1, XP_047304756.1, NP_001341637.1, XP_054203650.1, XP_047304770.1, XP_047304755.1, XP_047304751.1, XP_054203644.1, XP_054203669.1, XP_047304759.1, NP_001341639.1, XP_047304748.1, XP_047304746.1, XP_054203665.1, XP_054203654.1, XP_054203652.1, XP_054203656.1, NP_001361753.1, XP_047304747.1, XP_047304768.1, XP_047304764.1, XP_047304766.1, XP_054203660.1, XP_047304760.1, NP_001121649.1, NP_000452.2, NP_001239563.1, XP_054203672.1, XP_054203643.1, XP_054203645.1, XP_054203668.1, XP_054203662.1, XP_024309505.1, NP_001361752.1, XP_054203651.1, XP_054203653.1, XP_054203655.1, XP_011532349.1, NP_001341640.1, NP_001361755.1, XP_047304758.1, XP_047304773.1, XP_047304752.1, XP_047304772.1, NP_001121648.1, XP_054203671.1, XP_047304757.1, XP_047304753.1, XP_054203667.1, XP_054203663.1, XP_054203646.1, XP_047304769.1, XP_047304763.1, XP_047304767.1, XP_047304765.1, XP_054203675.1, XP_054203673.1

ZINC - World Drugs

THB_HUMAN

Guide to Pharmacology - Targets

589

OpenTargets

ENSG00000151090

ENSEMBL

ENSP00000496616, ENSP00000496029, ENST00000356447, ENSP00000494618, ENSP00000493709, ENSP00000496509, ENST00000643772, ENSP00000414444, ENST00000644321, ENST00000646432, ENST00000645139, ENSP00000379904, ENST00000646209, ENSP00000348827, ENST00000642307, ENSP00000280696, ENSG00000151090, ENSP00000496686, ENST00000416420, ENST00000396671, ENST00000280696

ZINC - FDA approved

THB_HUMAN

ZINC - Substances

THB_HUMAN

ZINC - Biogenic

THB_HUMAN

ZINC target

P10828

PRO

P10828

PDB

7WMN, 7WMO, 2NLL, 6KKB, 6KKE, 3D57, 8RQN, 1BSX, 1R6G, 1NUO, 3GWS, 1NQ2, 1N46, 1NQ1, 1NQ0, 2PIN, 7WLX, 7WMG, 1XZX, 7WMH, 9J0K, 9IX5, 6KNV, 6KNU, 6KNW, 7WMJ, 7WML, 1NAX, 1Y0X, 3IMY, 4ZO1, 2J4A, 1Q4X, 3JZC

ZINC - Investigational

THB_HUMAN

ZINC - Metabolites

THB_HUMAN

HPA

ENSG00000151090-THRB

GeneCards

THRB

Pharos - Targets

P10828

Orphanet

THRB

ZINC - Predictions - Purchasable

THB_HUMAN

HMDB Protein

HMDBP02896

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62736 ACTA2	1	ACTA2 [cytosol] (R-HSA-445792)	0.527	2
UniProt:Q9NR12 PDLIM7	1	PDLIM7 [cytosol] (R-HSA-8855085)	0.527	2
UniProt:Q562R1 ACTBL			0.527	2
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.527	2
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.508	2

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