PIAS1 SUMOylates THRB with SUMO1.

Stable Identifier
R-HSA-4719424
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS1 SUMOylates THRB with SUMO1.
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PIAS1 SUMOylates THRB with SUMO1 at lysine-50, lysine-146, and lysine-443 (Liu et al. 2012). SUMOylation is required for induction of gene expression in response to ligand (triiodothyroxine). In the absence of SUMOylation the repressor NCOR is not dismissed in response to ligand binding.

Literature References
PubMed ID Title Journal Year
22930759 Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation

Schultz, JJ, Liu, YY, Kogai, T, Mody, K, Brent, GA

J. Biol. Chem. 2012
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Output
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Catalyst Activity

SUMO transferase activity of PIAS1 [nucleoplasm]

Physical Entity
PIAS1 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1 SUMOylates THRB with SUMO1. (Bos taurus)
PIAS1 SUMOylates THRB with SUMO1. (Caenorhabditis elegans)
PIAS1 SUMOylates THRB with SUMO1. (Danio rerio)
PIAS1 SUMOylates THRB with SUMO1. (Gallus gallus)
PIAS1 SUMOylates THRB with SUMO1. (Mus musculus)
PIAS1 SUMOylates THRB with SUMO1. (Rattus norvegicus)
PIAS1 SUMOylates THRB with SUMO1. (Xenopus tropicalis)
Authored
May, B  (2013-10-18)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-19)
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