PIAS1 SUMOylates THRB with SUMO3

Stable Identifier
R-HSA-4719448
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PIAS1 SUMOylates THRB with SUMO3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PIAS1 SUMOylates THRB with SUMO3 at lysine-50, lysine-146, and lysine-443 (Liu et al. 2012). SUMOylation is required for induction of transcription in response to ligand binding.
Literature References
PubMed ID Title Journal Year
22930759 Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation

Liu, YY, Kogai, T, Schultz, JJ, Mody, K, Brent, GA

J. Biol. Chem. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of PIAS1 [nucleoplasm]

Physical Entity
PIAS1 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1 SUMOylates THRB with SUMO3 (Bos taurus)
PIAS1 SUMOylates THRB with SUMO3 (Danio rerio)
PIAS1 SUMOylates THRB with SUMO3 (Drosophila melanogaster)
PIAS1 SUMOylates THRB with SUMO3 (Mus musculus)
PIAS1 SUMOylates THRB with SUMO3 (Rattus norvegicus)
PIAS1 SUMOylates THRB with SUMO3 (Sus scrofa)
PIAS1 SUMOylates THRB with SUMO3 (Xenopus tropicalis)
Authored
May, B  (2013-10-18)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-19)
Cite Us!