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monoSUMO1-K50,K146,K443-THRB [nucleoplasm]
Stable Identifier
R-HSA-4719421
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Thyroid hormone receptor beta, THB_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS1 SUMOylates THRB with SUMO1. (Homo sapiens)
monoSUMO1-K50,K146,K443-THRB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10828 THRB
Gene Names
THRB, ERBA2, NR1A2, THR1
Chain
chain:1-461
Reference Genes
BioGPS Gene:7068 THRB
COSMIC (genes):THRB THRB
CTD Gene:7068 THRB
dbSNP Gene:7068 THRB
ENSEMBL:ENSG00000151090 THRB
ENSEMBL_homo_sapiens_GENE:ENSG00000151090.20 THRB
HGNC:11799 THRB
KEGG Gene (Homo sapiens):7068 THRB
Monarch:7068 THRB
NCBI Gene:7068 THRB
OMIM:190160 THRB
UCSC:P10828 THRB
Reference Transcript
RefSeq:XM_011534052.2 THRB
RefSeq:XM_011534051.2 THRB
RefSeq:XM_017007112.1 THRB
RefSeq:XM_011534046.2 THRB
RefSeq:XM_006713318.3 THRB
RefSeq:NM_001128177.1 THRB
RefSeq:NM_001128176.2 THRB
RefSeq:XM_017007111.1 THRB
RefSeq:XM_011534050.2 THRB
RefSeq:XM_017007110.1 THRB
RefSeq:XM_011534049.2 THRB
RefSeq:XM_006713317.3 THRB
RefSeq:XM_005265424.3 THRB
RefSeq:NM_000461.4 THRB
RefSeq:XM_017007109.1 THRB
RefSeq:XM_011534048.2 THRB
RefSeq:XM_017007108.1 THRB
RefSeq:XM_011534047.2 THRB
RefSeq:XM_005265423.4 THRB
RefSeq:XM_005265421.4 THRB
RefSeq:NM_001252634.1 THRB
Other Identifiers
11733998_a_at
11733999_a_at
11734000_a_at
11741355_a_at
11741923_a_at
11758048_s_at
11758574_s_at
1428_at
16951567
2048_s_at
207044_PM_at
207044_at
228716_PM_at
228716_at
229657_PM_at
229657_at
2666149
2666150
2666151
2666152
2666153
2666154
2666157
2666161
2666163
2666167
2666169
2666170
2666180
2666181
2666190
2666201
2666209
2666210
2666213
2666218
2666230
2666231
2666232
2666267
46013_at
59647_at
65078_at
7068
8085797
A_23_P80449
A_33_P3409974
A_33_P3663974
GE57894
GE594826
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001223
GO:0002154
GO:0002157
GO:0003013
GO:0003677
GO:0003682
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006351
GO:0006355
GO:0006357
GO:0007605
GO:0007621
GO:0008016
GO:0008050
GO:0008270
GO:0009887
GO:0012501
GO:0016071
GO:0016604
GO:0019899
GO:0022414
GO:0023052
GO:0030154
GO:0030522
GO:0031490
GO:0042789
GO:0043226
GO:0043565
GO:0045892
GO:0045944
GO:0046549
GO:0046872
GO:0048384
GO:0048856
GO:0050877
GO:0060089
GO:0060509
GO:0070324
GO:0090575
GO:0097067
GO:0097474
GO:0140110
GO:1990837
HMNXSV003023334
Hs.203213.0.A1_3p_at
Hs.203213.1.A1_3p_at
ILMN_1696683
PH_hs_0023016
PH_hs_0032153
TC03001241.hg
X04707_at
g10835122_3p_at
Participates
as an output of
PIAS1 SUMOylates THRB with SUMO1. (Homo sapiens)
Other forms of this molecule
polySUMO3-K50,K146,K443-THRB [nucleoplasm]
THRB [nucleoplasm]
Inferred To
monoSUMO1-K50,K146,K443-THRB [nucleoplasm]
(Danio rerio)
monoSUMO1-K50,K146,K443-THRB [nucleoplasm]
(Gallus gallus)
monoSUMO1-K50,K146,K443-THRB [nucleoplasm]
(Mus musculus)
monoSUMO1-K50,K146,K443-THRB [nucleoplasm]
(Rattus norvegicus)
Homologues of monoSUMO1-K50,K146,K443-THRB [nucleoplasm]
(Caenorhabditis elegans)
thrb [nucleoplasm]
(Xenopus tropicalis)
THRB [nucleoplasm]
(Bos taurus)
THRB [nucleoplasm]
(Sus scrofa)
nhr-2 [nucleoplasm]
(Caenorhabditis elegans)
nhr-7 [nucleoplasm]
(Caenorhabditis elegans)
nhr-85 [nucleoplasm]
(Caenorhabditis elegans)
sex-1 [nucleoplasm]
(Caenorhabditis elegans)
unc-55 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 50
Coordinate
50
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 146
Coordinate
146
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 443
Coordinate
443
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
XP_011532348.1
,
XP_011532352.1
,
XP_016862598.1
,
XP_005265481.1
,
XP_016862601.1
,
NP_000452.2
,
XP_011532353.1
,
XP_016862597.1
,
XP_011532349.1
,
XP_011532350.1
,
NP_001121648.1
,
NP_001121649.1
,
XP_016862600.1
,
XP_005265480.1
,
XP_011532351.1
,
XP_005265478.1
,
XP_011532354.1
,
XP_016862599.1
,
XP_006713381.1
,
XP_006713380.1
,
NP_001239563.1
ZINC - World Drugs
THB_HUMAN
Guide to Pharmacology - Targets
589
OpenTargets
ENSG00000151090
ZINC - FDA approved
THB_HUMAN
ZINC - Substances
THB_HUMAN
ZINC - Biogenic
THB_HUMAN
ZINC target
P10828
PRO
P10828
PDB
7WLX
,
7WMO
,
2NLL
,
1BSX
,
1NQ1
,
4ZO1
,
2PIN
,
1NQ2
,
7WMN
,
7WMG
,
3GWS
,
6KKE
,
6KNW
,
3D57
,
6KKB
,
2J4A
,
6KNU
,
6KNV
,
1Y0X
,
1R6G
,
7WMJ
,
1XZX
,
1N46
,
7WMH
,
1NAX
,
1NUO
,
1Q4X
,
7WML
,
3JZC
,
3IMY
,
1NQ0
ZINC - Investigational
THB_HUMAN
ZINC - Metabolites
THB_HUMAN
GeneCards
P10828
HPA
ENSG00000151090-THRB
Ensembl
ENST00000645139
,
ENSP00000379904
,
ENST00000643772
,
ENSP00000493709
,
ENSP00000494618
,
ENST00000396671
,
ENSP00000496509
,
ENST00000280696
,
ENSP00000414444
,
ENST00000416420
,
ENSP00000496616
,
ENSG00000151090
,
ENST00000642307
,
ENSP00000496029
,
ENST00000356447
,
ENST00000646209
,
ENSP00000496686
,
ENSP00000280696
,
ENSP00000348827
,
ENST00000646432
,
ENST00000644321
Pharos - Targets
P10828
Orphanet
15619
ZINC - Predictions - Purchasable
THB_HUMAN
HMDB Protein
HMDBP02896
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB(1-375) [nucleoplasm]
(R-HSA-3321990)
ACTB(1-375) [cytosol]
(R-HSA-201861)
ACTB(1-375) [lysosomal membrane]
(R-HSA-196160)
ACTB(1-375) [plasma membrane]
(R-HSA-196016)
0.527
2
UniProt:Q562R1 ACTBL
0.527
2
UniProt:Q9NR12 PDLIM7
1
PDLIM7 [cytosol]
(R-HSA-8855085)
0.527
2
UniProt:P62736 ACTA2
1
ACTA2 [cytosol]
(R-HSA-445792)
0.527
2
UniProt:Q60974 Ncor1
3
Ncor1 [cytosol]
(R-MMU-1253324)
Ncor1 [nucleoplasm]
(R-MMU-442459)
Ncor1 [nucleoplasm]
(R-MMU-442501)
0.508
2
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