Expression of HNF4A during nephron development

Stable Identifier
R-HSA-9832687
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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Expression of HNF4A during nephron development
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HNF4A is expressed in proximal tubules of developing nephrons and is required for formation of proximal tubules (inferred from mouse embryos). In the distal region of comma-shaped bodies and the proximal region of S-shaped bodies, HNF1B binds the promoter of the HNF4A gene and activates expression of HNF4A (inferred from mouse homologs). HNF4A in turn activates expression of a large number of genes encoding metabolic enzymes, transporters, and E-cadherin (CDH1), which is involved in epithelialization (inferred from mouse homologs).
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
HNF1B:HNF1A gene [nucleoplasm] (Homo sapiens)
Active Unit
HNF1B [nucleoplasm]
Inferred From
Expression of Hnf4a during nephron development (Mus musculus)
Authored
May, B  (2023-04-04)
Created
May, B  (2023-04-05)
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