Reactome | INSL5(23-48) [extracellular region]

INSL5(23-48) [extracellular region]

Stable Identifier

R-HSA-444855

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Insulin-like peptide 5 B chain, Insulin-like peptide INSL5, INSL5_HUMAN, INSL5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
        
        RXFP4 ligands [extracellular region] (Homo sapiens)
        
        Insulin-like peptide 5 [extracellular region] (Homo sapiens)
        
        INSL5(23-48) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
        
        RXFP4 ligands [extracellular region] (Homo sapiens)
        
        Insulin-like peptide 5 [extracellular region] (Homo sapiens)
        
        INSL5(23-48) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
        
        RXFP4 ligands [extracellular region] (Homo sapiens)
        
        Insulin-like peptide 5 [extracellular region] (Homo sapiens)
        
        INSL5(23-48) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
        
        RXFP4 ligands [extracellular region] (Homo sapiens)
        
        Insulin-like peptide 5 [extracellular region] (Homo sapiens)
        
        INSL5(23-48) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
        
        RXFP4 ligands [extracellular region] (Homo sapiens)
        
        Insulin-like peptide 5 [extracellular region] (Homo sapiens)
        
        INSL5(23-48) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
        
        RXFP4 ligands [extracellular region] (Homo sapiens)
        
        Insulin-like peptide 5 [extracellular region] (Homo sapiens)
        
        INSL5(23-48) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Relaxin receptors (Homo sapiens)
        
        Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)
        
        RXFP4 ligands [extracellular region] (Homo sapiens)
        
        Insulin-like peptide 5 [extracellular region] (Homo sapiens)
        
        INSL5(23-48) [extracellular region] (Homo sapiens)
        
        RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
        
        RXFP4 ligands [extracellular region] (Homo sapiens)
        
        Insulin-like peptide 5 [extracellular region] (Homo sapiens)
        
        INSL5(23-48) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5Q6 INSL5

Gene Names

INSL5, UNQ156/PRO182

Chain

signal peptide:1-22, peptide:23-46, propeptide:49-114, peptide:115-135

Reference Genes

BioGPS Gene:10022 INSL5

COSMIC (genes):INSL5 INSL5

CTD Gene:10022 INSL5

dbSNP Gene:10022 INSL5

ENSEMBL:ENSG00000172410 INSL5

ENSEMBL_homo_sapiens_GENE:ENSG00000172410.5 INSL5

HGNC:6088 INSL5

KEGG Gene (Homo sapiens):10022 INSL5

Monarch:10022 INSL5

NCBI Gene:10022 INSL5

OMIM:606413 INSL5

UCSC:Q9Y5Q6 INSL5

Reference Transcript

RefSeq:NM_005478.4 INSL5

Other Identifiers

10022

11738507_at

16688230

221091_PM_at

221091_at

2417009

2417010

2417011

2417012

2417013

7916785

A_23_P51479

GE477379

GO:0001664

GO:0005179

GO:0005515

GO:0005575

GO:0005576

GO:0007165

GO:0008150

GO:0023052

GO:0048018

GO:0098772

GO:2000253

HMNXSV003046168

ILMN_2060578

PH_hs_0013295

TC01002752.hg

g5729885_3p_at

Participates

as a component of

Insulin-like peptide 5 [extracellular region] (Homo sapiens)

Other forms of this molecule

INSL5(115-135) [extracellular region]

Inferred To

RFLA1 [extracellular region] (Danio rerio)

Insl5 [extracellular region] (Mus musculus)

Cross References

RefSeq

NP_005469.2

OpenTargets

ENSG00000172410

GeneCards

Q9Y5Q6

HPA

ENSG00000172410-INSL5

Ensembl

ENSG00000172410, ENSP00000302724, ENST00000304526

PRO

Q9Y5Q6

Pharos - Targets

Q9Y5Q6

PDB

7YJ4, 2KBC, 2K1V

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