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INSL5(115-135) [extracellular region]
Stable Identifier
R-HSA-444867
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Insulin-like peptide 5 A chain, Insulin-like peptide INSL5, INSL5_HUMAN, INSL5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 5 [extracellular region] (Homo sapiens)
INSL5(115-135) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 5 [extracellular region] (Homo sapiens)
INSL5(115-135) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 5 [extracellular region] (Homo sapiens)
INSL5(115-135) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 5 [extracellular region] (Homo sapiens)
INSL5(115-135) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 5 [extracellular region] (Homo sapiens)
INSL5(115-135) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 5 [extracellular region] (Homo sapiens)
INSL5(115-135) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Relaxin receptors (Homo sapiens)
Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 5 [extracellular region] (Homo sapiens)
INSL5(115-135) [extracellular region] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 5 [extracellular region] (Homo sapiens)
INSL5(115-135) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5Q6 INSL5
Gene Names
INSL5, UNQ156/PRO182
Chain
signal peptide:1-22, peptide:23-46, propeptide:49-114, peptide:115-135
Reference Genes
BioGPS Gene:10022 INSL5
COSMIC (genes):INSL5 INSL5
CTD Gene:10022 INSL5
dbSNP Gene:10022 INSL5
ENSEMBL:ENSG00000172410 INSL5
HGNC:6088 INSL5
KEGG:hsa:10022 INSL5
Monarch:10022 INSL5
NCBI Gene:10022 INSL5
OMIM:606413 INSL5
UCSC:Q9Y5Q6 INSL5
Reference Transcript
RefSeq:NM_005478.4 INSL5
Other Identifiers
10022
11738507_at
16688230
221091_PM_at
221091_at
2417009
2417010
2417011
2417012
2417013
7916785
A_23_P51479
GE477379
GO:0001664
GO:0005179
GO:0005515
GO:0005575
GO:0005576
GO:0007165
GO:0008150
GO:0048018
GO:0098772
GO:2000253
HMNXSV003046168
ILMN_2060578
PH_hs_0013295
TC01002752.hg
g5729885_3p_at
Participates
as a component of
Insulin-like peptide 5 [extracellular region] (Homo sapiens)
Other forms of this molecule
INSL5(23-48) [extracellular region]
Inferred To
insl5a [extracellular region]
(Danio rerio)
Insl5 [extracellular region]
(Mus musculus)
Cross References
RefSeq
NP_005469.2
ENSEMBL
ENST00000304526
,
ENSP00000302724
OpenTargets
ENSG00000172410
HPA
ENSG00000172410-INSL5
PRO
Q9Y5Q6
Pharos - Targets
Q9Y5Q6
PDB
2K1V
,
7YJ4
,
2KBC
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92824 PCSK5
2
PCSK5 [extracellular region]
(R-HSA-6784682)
PCSK5(115-913) [Golgi lumen]
(R-HSA-166558)
0.527
2
UniProt:O43529 CHST10
1
CHST10 [Golgi membrane]
(R-HSA-6786025)
0.527
2
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