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PCSK5(115-913) [Golgi lumen]
Stable Identifier
R-HSA-166558
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
Convertase PC5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Expression and Processing of Neurotrophins (Homo sapiens)
NGF processing (Homo sapiens)
Part of pro-beta-NGF is processed to mature beta-NGF (Homo sapiens)
Subtilisin/kexin convertase (Calcium dependant) [Golgi lumen] (Homo sapiens)
Subtilisin/kexin-like convertase [Golgi lumen] (Homo sapiens)
PCSK5(115-913) [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92824 PCSK5
Gene Names
PCSK5, PC5, PC6
Chain
signal peptide:1-32, propeptide:33-114, chain:115-1860
Reference Genes
BioGPS Gene:5125 PCSK5
COSMIC (genes):PCSK5 PCSK5
CTD Gene:5125 PCSK5
dbSNP Gene:5125 PCSK5
ENSEMBL:ENSG00000099139 PCSK5
ENSEMBL:ENSG00000099139.14 PCSK5
HGNC:8747 PCSK5
KEGG Gene (Homo sapiens):5125 PCSK5
Monarch:5125 PCSK5
NCBI Gene:5125 PCSK5
OMIM:600488 PCSK5
UCSC:Q92824 PCSK5
Reference Transcript
RefSeq:NM_001190482.1 PCSK5
RefSeq:NM_006200.5 PCSK5
Other Identifiers
11724687_a_at
11758913_at
17085998
205559_PM_s_at
205559_s_at
205560_PM_at
205560_at
213652_PM_at
213652_at
3169962
3175275
3175276
3175277
3175284
3175285
3175293
3175294
3175295
3175296
3175300
3175302
3175309
3175310
3175312
3175315
3175317
3175320
3175321
3175322
3175325
3175329
3175330
3175332
3175334
3175335
3175337
3175338
3175339
3175340
3175341
3175342
3175345
3175346
3175349
3175351
3175352
3175356
3175359
3175360
3175361
3175366
3175367
3175369
3175370
3175371
3175372
3175373
3175376
3175377
3175378
3175379
3175381
3175382
3175383
3175384
3175441
3175443
3175445
3175447
41032_at
5125
60802_at
8155898
A_14_P131468
A_23_P257003
A_24_P355246
A_33_P3358731
A_33_P3358735
GE59247
GE86297
GE86298
GO:0001822
GO:0002001
GO:0003013
GO:0003014
GO:0003824
GO:0004175
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005794
GO:0005796
GO:0005802
GO:0006465
GO:0006508
GO:0007267
GO:0007507
GO:0007565
GO:0007566
GO:0008233
GO:0008236
GO:0009952
GO:0012505
GO:0016020
GO:0016485
GO:0016486
GO:0016787
GO:0019058
GO:0022414
GO:0023052
GO:0030323
GO:0035108
GO:0042277
GO:0043043
GO:0043226
GO:0048566
GO:0048706
GO:0048856
GO:0050790
GO:0050886
GO:0051004
GO:0051604
GO:0140096
GO:0140447
HMNXSV003044830
HMNXSV003045947
Hs.288931.0.S1_3p_at
ILMN_1767934
ILMN_1819750
PH_hs_0015012
TC09000347.hg
U49114_at
g11321618_3p_at
Participates
as a member of
Subtilisin/kexin-like convertase [Golgi lumen] (Homo sapiens)
Other forms of this molecule
PCSK5 [extracellular region]
Inferred To
Pcsk5 [Golgi lumen]
(Mus musculus)
Pcsk5 [Golgi lumen]
(Rattus norvegicus)
PCSK5 [Golgi lumen]
(Bos taurus)
PCSK5 [Golgi lumen]
(Sus scrofa)
PCSK5(115-913) [Golgi lumen]
(Canis familiaris)
PCSK5(115-913) [Golgi lumen]
(Danio rerio)
PCSK5(115-913) [Golgi lumen]
(Gallus gallus)
Cross References
RefSeq
NP_006191.2
,
NP_001177411.1
Guide to Pharmacology - Targets
2385
OpenTargets
ENSG00000099139
ZINC - Substances
PCSK5_HUMAN
HPA
ENSG00000099139-PCSK5
GeneCards
Q92824
ZINC target
Q92824
Ensembl
ENST00000545128
,
ENSG00000099139
,
ENSP00000365943
,
ENSP00000446280
,
ENST00000376752
PRO
Q92824
Pharos - Targets
Q92824
Orphanet
24792
ZINC - Predictions - Purchasable
PCSK5_HUMAN
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-10171679 386682
0.556
3
UniProt:O75716 STK16
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q7Z3S9 NT2NA
0.556
3
UniProt:Q9BQ66 KR412
0.556
3
UniProt:Q7Z417 NUFP2
0.556
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
UniProt:Q5T5A8 LCE3C
1
LCE3C [cytosol]
(R-HSA-6814279)
0.556
3
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.556
3
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