Reactome | PCSK5(115-913) [Golgi lumen]

PCSK5(115-913) [Golgi lumen]

Stable Identifier

R-HSA-166558

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

Convertase PC5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Expression and Processing of Neurotrophins (Homo sapiens)
      - NGF processing (Homo sapiens)
        
        Part of pro-beta-NGF is processed to mature beta-NGF (Homo sapiens)
        
        Subtilisin/kexin convertase (Calcium dependant) [Golgi lumen] (Homo sapiens)
        
        Subtilisin/kexin-like convertase [Golgi lumen] (Homo sapiens)
        
        PCSK5(115-913) [Golgi lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92824 PCSK5

Gene Names

PCSK5, PC5, PC6

Chain

signal peptide:1-32, propeptide:33-114, chain:115-1860

Reference Genes

COSMIC (genes):PCSK5 PCSK5

dbSNP Gene:5125 PCSK5

ENSEMBL:ENSG00000099139 PCSK5

Participates

as a member of

Subtilisin/kexin-like convertase [Golgi lumen] (Homo sapiens)

Other forms of this molecule

PCSK5 [extracellular region]

Inferred To

pcsk5b [Golgi lumen] (Danio rerio)

Pcsk5 [Golgi lumen] (Mus musculus)

Pcsk5 [Golgi lumen] (Rattus norvegicus)

PCSK5 [Golgi lumen] (Bos taurus)

PCSK5 [Golgi lumen] (Canis familiaris)

pcsk5 [Golgi lumen] (Xenopus tropicalis)

PCSK5(115-913) [Golgi lumen] (Gallus gallus)

PCSK5(115-913) [Golgi lumen] (Sus scrofa)

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-10171679 386682			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q9BQ66 KR412			0.556	3
UniProt:Q7Z417 NUFP2			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q5T5A8 LCE3C	1	LCE3C [cytosol] (R-HSA-6814279)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
UniProt:Q03405 PLAUR	7	PLAUR [endoplasmic reticulum membrane] (R-HSA-162703) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [specific granule membrane] (R-HSA-6806143)	0.527	2
UniProt:P13727 PRG2	2	PRG2 [extracellular region] (R-HSA-6806492) PRG2 [ficolin-1-rich granule lumen] (R-HSA-6801280)	0.527	3
UniProt:Q96T91 GPHA2	1	GPHA2 [extracellular region] (R-HSA-8942422)	0.527	2
UniProt:P09093 CEL3A			0.527	2
UniProt:Q9Y5Q6 INSL5	2	INSL5(115-135) [extracellular region] (R-HSA-444867) INSL5(23-48) [extracellular region] (R-HSA-444855)	0.527	2
UniProt:O15496 PLA2G10	1	PLA2G10 [extracellular region] (R-HSA-1498793)	0.527	2
UniProt:Q9Y2Y8 PRG3	3	PRG3 [tertiary granule lumen] (R-HSA-6800905) PRG3 [extracellular region] (R-HSA-6806299) PRG3 [specific granule lumen] (R-HSA-6799555)	0.527	2

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