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REPS2 [cytosol]
Stable Identifier
R-HSA-432938
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
POB1, RalBP1-associated Eps domain-containing protein 2, REPS2_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
REPS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NFH8 REPS2
Gene Names
REPS2, POB1
Chain
chain:1-660
Reference Genes
BioGPS Gene:9185 REPS2
COSMIC (genes):REPS2 REPS2
CTD Gene:9185 REPS2
dbSNP Gene:9185 REPS2
ENSEMBL:ENSG00000169891 REPS2
ENSEMBL_homo_sapiens_GENE:ENSG00000169891.18 REPS2
HGNC:9963 REPS2
KEGG Gene (Homo sapiens):9185 REPS2
Monarch:9185 REPS2
NCBI Gene:9185 REPS2
OMIM:300317 REPS2
UCSC:Q8NFH8 REPS2
Reference Transcript
RefSeq:NM_004726.2 REPS2
RefSeq:NM_001080975.1 REPS2
Other Identifiers
11722347_a_at
11722348_a_at
17101828
205645_PM_at
205645_at
227425_PM_at
227425_at
242571_PM_at
242571_at
3970215
3970216
3970217
3970230
3970231
3970235
3970238
3970239
3970240
3970249
3970250
3970251
3970253
3970254
3970256
3970258
3970262
3970267
3970275
3970276
3970280
3970281
3970282
3970283
3970308
40663_at
46131_at
8166243
9185
A_14_P200877
A_23_P251387
A_33_P3357470
GE54102
GE594083
GO:0005509
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006897
GO:0007173
GO:0016192
GO:0016197
GO:0023052
GO:0046872
GO:0065003
HMNXSV003031410
HMNXSV003054880
Hs.257661.0.A1_3p_at
Hs.5740.0.A1_3p_at
ILMN_1656934
ILMN_1724668
ILMN_1759633
ILMN_1766425
ILMN_2405797
PH_hs_0000583
PH_hs_0023855
TC0X000082.hg
TC0X001610.hg
g4758943_3p_at
Participates
as a component of
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
Inferred To
Reps [cytosol]
(Drosophila melanogaster)
REPS2 [cytosol]
(Canis familiaris)
REPS2 [cytosol]
(Gallus gallus)
REPS2 [cytosol]
(Mus musculus)
REPS2 [cytosol]
(Sus scrofa)
reps2 [cytosol]
(Xenopus tropicalis)
Reps2 [cytosol]
(Rattus norvegicus)
Ghost homologue of REPS2 [cytosol]
(Bos taurus)
Ghost homologue of REPS2 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of REPS2 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_004717.2
,
NP_001074444.1
OpenTargets
ENSG00000169891
GeneCards
Q8NFH8
HPA
ENSG00000169891-REPS2
Ensembl
ENSG00000169891
,
ENSP00000349824
,
ENST00000357277
,
ENST00000303843
,
ENSP00000306033
PRO
Q8NFH8
Pharos - Targets
Q8NFH8
PDB
1IQ3
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6I3 EPN1
2
EPN1 [plasma membrane]
(R-HSA-182952)
EPN1 [cytosol]
(R-HSA-8865826)
0.609
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.602
8
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.544
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.524
2
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