Reactome | EPS15 [cytosol]

EPS15 [cytosol]

Stable Identifier

R-MMU-182920

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P42567

Locations in the PathwayBrowser

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Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        UBQLN2:UIM-containing proteins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - Epsin family proteins bind ubiquitinated cargo (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - UBQLNs bind UIM-containing adaptor proteins (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        UNQLNs:UIM proteins [cytosol] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - Recruitment of AP-2 complex and clathrin (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Mus musculus)
        
        EPS15,EPN1,EPN2 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)
        
        EPS15 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P42567

Reference Genes

BioGPS Gene:13858

ENSEMBL:ENSMUSG00000028552

ENSEMBL:ENSMUSG00000028552.14

KEGG Gene (Mus musculus):13858

Monarch:13858

NCBI Gene:13858

UCSC:P42567

Reference Transcript

Other Identifiers

104006_at

104367_at

10506939

13858

1419251_at

1419252_at

17416830

4364647

4575799

4614341

4637585

4660341

4743563

4778583

4821465

4834425

4849043

4879976

4933800

5002031

5030396

5030887

5048515

5064017

5142265

5167942

5204428

5310376

5315609

5347282

5358827

5384191

5404760

5496743

5503373

5507050

5568284

5612501

A_51_P156243

A_52_P360595

A_55_P2483133

A_55_P2815434

GE34348

GO:0001921

GO:0005509

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0005905

GO:0005929

GO:0006895

GO:0006897

GO:0009925

GO:0015031

GO:0016020

GO:0016192

GO:0016197

GO:0016235

GO:0016324

GO:0017124

GO:0019065

GO:0023052

GO:0030122

GO:0030132

GO:0030136

GO:0031410

GO:0031593

GO:0031901

GO:0032456

GO:0032880

GO:0042127

GO:0042802

GO:0043130

GO:0043226

GO:0043231

GO:0045202

GO:0046718

GO:0046872

GO:0048268

GO:0060170

GO:0065003

GO:0070086

GO:0098794

GO:0098884

GO:0098978

ILMN_1228338

ILMN_1258559

L21768_s_at

mMC016350

mMR026252

Participates

as a component of

as a member of

EPS15,EPN1,EPN2 [cytosol] (Mus musculus)

Other forms of this molecule

phospho-p-Y849 EPS15 [cytosol]

Inferred From

EPS15 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001153436.1, NP_031969.1

Ensembl

ENSMUSG00000028552, ENSMUST00000102729, ENSMUSP00000099790

PRO

P42567

MGI

104583

PDB

1QJT, 1KYF, 1KYU

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