Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)

Stable Identifier
R-HSA-432232
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated Protein Kinase A phosphorylates Aquaporin-2 at Serine 256. The phosphorylated form of AQP2 then traffics from intracellular vesicles to the apical plasma membrane.

Literature References
PubMed ID Title Journal Year
12194985 The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel

van Balkom, BW, Savelkoul, PJ, Markovich, D, Hofman, E, Nielsen, S, van der Sluijs, P, Deen, PM

J Biol Chem 2002
9227644 Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells

Katsura, T, Gustafson, CE, Ausiello, DA, Brown, D

Am J Physiol 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cAMP-dependent protein kinase activity of PKA catalytic subunit [cytosol]
Physical Entity
Activity
Orthologous Events
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